Model peptide studies of Ag+ binding sites from the silver resistance protein SilE,Chemical Communications

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Model peptide studies of Ag+ binding sites from the silver resistance protein SilE
Chemical Communications ( IF 4.3 ) Pub Date : 2017-05-11 00:00:00 , DOI: 10.1039/c7cc02630g
V. Chabert _{1,

2,

3,

4} , M. Hologne _{5,

6,

7,

8,

9} , O. Sénèque _{6,

10,

11,

12,

13} , A. Crochet _{1,

3,

4,

14,

15} , O. Walker _{5,

6,

7,

8,

9} , K. M. Fromm _{1,

2,

3,

4}

Affiliation

Using model peptides, each of the nine MX₂H or HX_nM (n = 1, 2) motifs of the silver resistance protein SilE has been shown to coordinate to one Ag⁺ ion by its histidine and methionine residues with K_d in the μM range. This suggests an Ag⁺ buffering role for SilE in the case of high Ag⁺ overload.

中文翻译：

银抗性蛋白SilE中Ag ⁺结合位点的模型肽研究

使用模型肽，已显示出银抗性蛋白SilE的9个MX ₂ H或HX _n M（n = 1，2）基序中的每一个均通过其组氨酸和蛋氨酸残基中的K _d与一个Ag ⁺离子配位。 μM范围。这表明在高Ag ⁺过载的情况下，SilE具有Ag ⁺缓冲作用。

更新日期：2017-05-22

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