Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes,Journal of the American Chemical Society

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Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-05-19 , DOI: 10.1021/jacs.7b03749
Fei Ye ₁ , Junting Chen ₁ , Tobias Ritter ₁

Affiliation

We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance. The hydrocyanation reaction employs acetone cyanohydrin as a practical alternative to HCN gas.

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