The precision and efficacy of photodynamic therapy (PDT) is essential for the treatment of brain tumors because the cancer cells are within or adjacent to the delicate nervous system. Taurine is an abundant amino acid in the brain that serves the central nervous system (CNS). A taurine-modified polypyridyl Ru-complex was shown to have optimized intracellular affinity in cancer cells through accumulation in lysosomes. Symmetrical modification of this Ru-complex by multiple taurine molecules enhanced the efficiency of molecular emission with boosted generation of reactive oxygen species. These characteristic features make the taurine-modified Ru-complex a potentially effective photosensitizer for PDT of target cancer cells, with outstanding efficacy in cancerous brain cells.

中文翻译：

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牛磺酸修饰的Ru（II）络合物靶向癌性脑细胞进行光动力治疗

光动力疗法（PDT）的精确性和有效性对于脑肿瘤的治疗至关重要，因为癌细胞位于脆弱的神经系统之内或附近。牛磺酸是大脑中为中枢神经系统（CNS）服务的丰富氨基酸。牛磺酸修饰的聚吡啶基Ru-复合物通过在溶酶体中积累，在癌细胞中具有优化的细胞内亲和力。多个牛磺酸分子对这种Ru复合物的对称修饰提高了分子发射效率，并增加了活性氧的产生。这些特征使牛磺酸修饰的Ru-络合物成为对靶癌细胞PDT的潜在有效的光敏剂，在脑癌细胞中具有出色的功效。