Dysregulated autography is associated with a variety of conditions, including cancer, neurodegenerative diseases, cardiovascular disorders and infectious diseases. However, despite significant efforts, no specific modulators of autophagy have yet been moved into the clinic. Here, Galluzzi et al. discuss the therapeutic potential of autophagy modulators and consider the key challenges that have limited their development.

中文翻译：

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自噬的药理学调节：治疗潜力和持续存在的障碍

自闭症造影不良与多种疾病有关，包括癌症，神经退行性疾病，心血管疾病和感染性疾病。然而，尽管作出了巨大的努力，但尚未将自噬的特定调节剂引入临床。在这里，Galluzzi等人。讨论自噬调节剂的治疗潜力，并考虑限制其发展的关键挑战。