A general synthesis of highly functionalized ferrocenes, which include (P,B)- and (N,B)-ambiphiles, has been developed at a multigram scale. Diastereoselective stepwise modification of di-tert-butylated ferrocenes included the unprecedented separation of electroactive species. Bulky alkyl groups on ferrocenes ensure planar chirality of ambiphiles and enforce closer proximity of antagonist Lewis functions.

中文翻译：

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通过电化学纯化可大规模大规模合成高官能化二茂铁二茂铁的非对映选择性

已经以克数级开发了包括（P，B）-和（N，B）-两亲物的高度官能化的二茂铁的一般合成。二叔丁基化二茂铁的非对映选择性逐步修饰包括前所未有的电活性物质分离。二茂铁上的大烷基确保了两亲物的平面手性，并增强了拮抗路易斯的功能。