Drug combinations are commonly used to counter drug resistance in cancer therapy. To identify synergistic drug target combinations, Han et al. have developed a scalable CRISPR-based double-knockout system that enables parallel pairwise gene knockout. Application of this system in a chronic myeloid leukaemia (CML)

中文翻译：

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癌症：确定协同药物组合

药物组合通常用于抵抗癌症治疗中的耐药性。为了鉴定协同药物靶标组合​​，Han等。已经开发了可扩展的基于CRISPR的双敲除系统，可实现平行配对基因敲除。该系统在慢性粒细胞白血病（CML）中的应用