Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

中文翻译：

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查耳酮：药物化学中的一种特殊结构

特权结构已被广泛用作药物发现药物化学的有效模板。查耳酮是在许多天然化合物中发现的常见简单支架。由于合成方便，许多查尔酮衍生物也被制备出来。这些天然产物和合成化合物显示出许多有趣的生物活性，具有对抗各种疾病的临床潜力。本综述旨在强调查耳酮作为药物化学中的特殊支架的最新证据。本文将总结查耳酮的多个方面，包括新型查耳酮衍生物的分离、新合成方法的开发、其生物学特性的评估、作用机制的探索以及靶点识别。这篇综述预计将成为化学界对查耳酮模板的全面、权威和批判性的综述。