Signal Sensing and Transduction by Histidine Kinases as Unveiled through Studies on a Temperature Sensor,Accounts of Chemical Research

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Signal Sensing and Transduction by Histidine Kinases as Unveiled through Studies on a Temperature Sensor
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-05-05 00:00:00 , DOI: 10.1021/acs.accounts.6b00593
Luciano A. Abriata _{1,

2} , Daniela Albanesi ₃ , Matteo Dal Peraro _{1,

2} , Diego de Mendoza ₃

Affiliation

Histidine kinases (HK) are the sensory proteins of two-component systems, responsible for a large fraction of bacterial responses to stimuli and environmental changes. Prototypical HKs are membrane-bound proteins that phosphorylate cognate response regulator proteins in the cytoplasm upon signal detection in the membrane or periplasm. HKs stand as potential drug targets but also constitute fascinating systems for studying proteins at work, specifically regarding the chemistry and mechanics of signal detection, transduction through the membrane, and regulation of catalytic outputs.

中文翻译：

通过对温度传感器的研究揭示的组氨酸激酶的信号传感和转导

组氨酸激酶（HK）是两组分系统的感觉蛋白，负责细菌对刺激和环境变化的很大一部分反应。典型的HKs是膜结合蛋白，其在膜或周质中检测到信号后使细胞质中的同源响应调节蛋白磷酸化。HKs是潜在的药物靶标，但也构成了研究工作中蛋白质的引人入胜的系统，特别是在信号检测的化学和力学，通过膜的转导以及催化输出的调节方面。

更新日期：2017-05-05

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