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Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
Nature Reviews Drug Discovery ( IF 122.7 ) Pub Date : 2017-05-05 00:00:00 , DOI: 10.1038/nrd.2017.33 Veaceslav Boldescu 1, 2 , Mira A M Behnam 1 , Nikos Vasilakis 3 , Christian D Klein 1
Nature Reviews Drug Discovery ( IF 122.7 ) Pub Date : 2017-05-05 00:00:00 , DOI: 10.1038/nrd.2017.33 Veaceslav Boldescu 1, 2 , Mira A M Behnam 1 , Nikos Vasilakis 3 , Christian D Klein 1
Affiliation
Flaviviruses, including dengue and Zika viruses, are of substantial public health concern. Klein and colleagues review the development of broad-spectrum antiviral agents that would target many of the known and potentially unknown flaviviruses. The benefits and caveats of molecules that target either viral proteins or host mechanisms exploited by these viruses are discussed.
中文翻译:
治疗黄病毒感染的广谱药物:登革热、寨卡病毒等
黄病毒,包括登革热和寨卡病毒,是严重的公共卫生问题。克莱因和同事回顾了针对许多已知和潜在未知黄病毒的广谱抗病毒药物的开发。讨论了针对病毒蛋白或这些病毒利用的宿主机制的分子的优点和注意事项。
更新日期:2017-05-18
中文翻译:
治疗黄病毒感染的广谱药物:登革热、寨卡病毒等
黄病毒,包括登革热和寨卡病毒,是严重的公共卫生问题。克莱因和同事回顾了针对许多已知和潜在未知黄病毒的广谱抗病毒药物的开发。讨论了针对病毒蛋白或这些病毒利用的宿主机制的分子的优点和注意事项。