Bioinspired assembly of small molecules in cell milieu,Chemical Society Reviews

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Bioinspired assembly of small molecules in cell milieu
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-03-30 00:00:00 , DOI: 10.1039/c6cs00656f
Huaimin Wang _{1,

2,

3,

4} , Zhaoqianqi Feng _{1,

2,

3,

4} , Bing Xu _{1,

2,

3,

4}

Affiliation

Self-assembly, the autonomous organization of components to form patterns or structures, is a prevalent process in nature at all scales. Particularly, biological systems offer remarkable examples of diverse structures (as well as building blocks) and processes resulting from self-assembly. The exploration of bioinspired assemblies not only allows for mimicking the structures of living systems, but it also leads to functions for applications in different fields that benefit humans. In the last several decades, efforts on understanding and controlling self-assembly of small molecules have produced a large library of candidates for developing the biomedical applications of assemblies of small molecules. Moreover, recent findings in biology have provided new insights on the assemblies of small molecules to modulate essential cellular processes (such as apoptosis). These observations indicate that the self-assembly of small molecules, as multifaceted entities and processes to interact with multiple proteins, can have profound biological impacts on cells. In this review, we illustrate that the generation of assemblies of small molecules in cell milieu with their interactions with multiple cellular proteins for regulating cellular processes can result in primary phenotypes, thus providing a fundamentally new molecular approach for controlling cell behavior. By discussing the correlation between molecular assemblies in nature and the assemblies of small molecules in cell milieu, illustrating the functions of the assemblies of small molecules, and summarizing some guiding principles, we hope this review will stimulate more molecular scientists to explore the bioinspired self-assembly of small molecules in cell milieu.

中文翻译：

生物启发的细胞环境中小分子组装

自组装是组件的自主组织以形成图案或结构，实际上在所有规模上都是普遍存在的过程。特别是，生物系统提供了自组装产生的各种结构（以及构建基块）和过程的非凡示例。对受生物启发的组件的探索不仅可以模仿生命系统的结构，而且还可以为在不同领域中有益于人类的应用提供功能。在过去的几十年中，在理解和控制小分子自组装方面的努力产生了一个庞大的候选库，用于开发小分子组装的生物医学应用。而且，生物学的最新发现为小分子的组装提供了新的见解，以调节必要的细胞过程（例如细胞凋亡）。这些观察结果表明，小分子的自组装作为多方面的实体以及与多种蛋白质相互作用的过程，可以对细胞产生深远的生物学影响。在这篇综述中，我们说明了细胞环境中小分子装配的产生以及它们与调控细胞过程的多种细胞蛋白的相互作用可以导致初级表型，从而为控制细胞行为提供了根本上新的分子方法。通过讨论自然界中的分子组装体与细胞环境中小分子组装体之间的相关性，说明了小分子组装体的功能，

更新日期：2017-05-04

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