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Assessing cooperativity in supramolecular systems
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-03-29 00:00:00 , DOI: 10.1039/c7cs00063d
Larissa K. S. von Krbek 1, 2, 3, 4 , Christoph A. Schalley 1, 2, 3, 4 , Pall Thordarson 5, 6, 7, 8
Affiliation  

This tutorial review summarises different aspects of cooperativity in supramolecular complexes. We propose a systematic categorisation of cooperativity into cooperative aggregation, intermolecular (allosteric) cooperativity, intramolecular (chelate) cooperativity and interannular cooperativity and discuss approaches to quantify them thermodynamically using cooperativity factors. A brief summary of methods to determine the necessary thermodynamic data is given with emphasis on isothermal titration calorimetry (ITC), a method still underrepresented in supramolecular chemistry, which however offers some advantages over others. Finally, a discussion of very few selected examples, which highlight different aspects to illustrate why such an analysis is useful, rounds up this review.

中文翻译:

评估超分子系统中的协同性

本教程概述总结了超分子复合物中协同作用的不同方面。我们提出了将合作性分为合作聚集,分子间(别构)合作性,分子内(螯合物)合作性和环间合作性的系统分类,并讨论了使用合作性因素对它们进行热力学定量的方法。简要介绍了确定必要的热力学数据的方法,重点是等温滴定热量法(ITC),该方法在超分子化学中仍然没有得到很好的体现,但是与其他方法相比,它具有一些优势。最后,仅对很少的示例进行了讨论,这些示例突出了不同方面,以说明为什么进行这种分析是有用的,从而使本综述更加全面。
更新日期:2017-05-04
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