Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots,Chemical Society Reviews

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Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-03-22 00:00:00 , DOI: 10.1039/c7cs00030h
H. Hess _{1,

2,

3} , Jennifer L. Ross _{3,

4,

5}

Affiliation

Biological systems have evolved to harness non-equilibrium processes from the molecular to the macro scale. It is currently a grand challenge of chemistry, materials science, and engineering to understand and mimic biological systems that have the ability to autonomously sense stimuli, process these inputs, and respond by performing mechanical work. New chemical systems are responding to the challenge and form the basis for future responsive, adaptive, and active materials. In this article, we describe a particular biochemical–biomechanical network based on the microtubule cytoskeletal filament – itself a non-equilibrium chemical system. We trace the non-equilibrium aspects of the system from molecules to networks and describe how the cell uses this system to perform active work in essential processes. Finally, we discuss how microtubule-based engineered systems can serve as testbeds for autonomous chemical robots composed of biological and synthetic components.

中文翻译：

微管的非平衡组装：从分子到自主化学机器人

生物系统已经发展到可以利用从分子到宏观尺度的非平衡过程。目前，化学，材料科学和工程学面临巨大挑战，即如何理解和模拟能够自主感知刺激，处理这些输入并通过执行机械工作做出反应的生物系统。新的化学系统正在应对挑战，并为未来的响应式，适应性和活性材料奠定了基础。在本文中，我们描述了基于微管细胞骨架丝的特殊生化-生物力学网络-本身是非平衡化学系统。我们追踪了从分子到网络的系统非平衡方面，并描述了细胞如何利用该系统在基本过程中执行主动工作。最后，

更新日期：2017-05-04

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