Synthetic mimics of biotin/(strept)avidin,Chemical Society Reviews

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Synthetic mimics of biotin/(strept)avidin
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-02-13 00:00:00 , DOI: 10.1039/c7cs00011a
Wenqi Liu _{1,

2,

3,

4} , Soumen K. Samanta _{1,

4,

5,

6} , Bradley D. Smith _{1,

2,

3,

4} , Lyle Isaacs _{1,

4,

5,

6}

Affiliation

Biotin/(strept)avidin self-assembly is a powerful platform for nanoscale fabrication and capture with many different applications in science, medicine, and nanotechnology. However, biotin/(strept)avidin self-assembly has several well-recognized drawbacks that limit performance in certain technical areas and there is a need for synthetic mimics that can either become superior replacements or operational partners with bio-orthogonal recognition properties. The goal of this tutorial review is to describe the recent progress in making high affinity synthetic association partners that operate in water or biological media. The review starts with a background summary of biotin/(strept)avidin self-assembly and the current design rules for creating synthetic mimics. A series of case studies are presented that describe recent success using synthetic derivatives of cyclodextrins, cucurbiturils, and various organic cyclophanes such as calixarenes, deep cavitands, pillararenes, and tetralactams. In some cases, two complementary partners associate to produce a nanoscale complex and in other cases a ditopic host molecule is used to link two partners. The article concludes with a short discussion of future directions and likely challenges.

中文翻译：

生物素/（链）亲和素的合成模拟物

生物素/（链）亲和素自组装是一个强大的平台，可用于纳米级制造和捕获，在科学，医学和纳米技术中具有许多不同的应用。然而，生物素/（链）亲和素自组装具有几个公认的缺点，这些缺点限制了某些技术领域的性能，并且需要合成模拟物，其可以成为具有生物正交识别特性的高级替代品或操作伙伴。本教程复习的目的是描述在水或生物介质中运作的高亲和力合成缔合伙伴的最新进展。审查从生物素/（链霉亲和素）亲和素自组装的背景摘要以及用于创建合成模拟物的当前设计规则开始。本文介绍了一系列案例研究，这些案例描述了使用环糊精，葫芦丝和各种有机环烷（如杯芳烃，深空泡石，柱芳烃和四内酰胺）的合成衍生物取得的近期成功。在某些情况下，两个互补配偶体缔合以产生纳米级复合物，而在其他情况下，使用双位宿主分子连接两个配偶体。本文最后对未来的方向和可能的挑战进行了简短的讨论。

更新日期：2017-05-04

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