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EGFR and HER2 activate rigidity sensing only on rigid matrices
Nature Materials ( IF 37.2 ) Pub Date : 2017-05-01 00:00:00 , DOI: 10.1038/nmat4893
Mayur Saxena 1 , Shuaimin Liu 2 , Bo Yang 3 , Cynthia Hajal 2 , Rishita Changede 3 , Junqiang Hu 2 , Haguy Wolfenson 4, 5 , James Hone 2 , Michael P Sheetz 3, 4
Affiliation  

Epidermal growth factor receptor and its isoform HER2 are recruited to nascent cellular adhesion sites and play an important role in the rigidity sensing of cells on stiff substrates, this activity being dependent on Src-mediated phosphorylation.

中文翻译:


EGFR 和 HER2 仅在刚性基质上激活刚性传感



表皮生长因子受体及其亚型 HER2 被募集到新生细胞粘附位点,并在坚硬基质上的细胞刚性感应中发挥重要作用,这种活性依赖于 Src 介导的磷酸化。
更新日期:2017-05-18
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