The development of oral insulin-sensitizing agents to minimize the need for injectable insulin remains a major unmet need in the treatment of diabetes. Now, writing in Nature Chemical Biology, Bottini and colleagues report the identification of the first orally available small-molecule inhibitor of the

中文翻译：

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代谢性疾病：蛋白酪氨酸磷酸酶抑制剂可逆转糖尿病

开发口服胰岛素增敏剂以最小化对可注射胰岛素的需求仍然是治疗糖尿病的主要未满足需求。现在，Bottini及其同事在《自然化学生物学》上发表的文章报道了鉴定出的第一种口服可获得的小分子抑制剂。