Exosomes—small, membrane-derived extracellular vesicles capable of carrying diverse biological cargo including proteins and microRNAs—have been found in a broad range of biological fluids and appear to be predominantly involved in cell-to-cell communication. Their natural characteristics make them uniquely suited for research and clinical applications, including as biomarkers both for diseases and for intrinsic biological activity. In fact, exosomes have been postulated to mediate the biological cross-talk that takes place between tumors and their surrounding environment that drives those tumors toward a metastatic state. In addition, exosomes are being co-opted as a treatment modality and have been modified through their parental cells to express a targeting moiety or marker tag on their surface. They can also be manipulated to carry drug formulations that can be applied to the treatment of a wide variety of disorders, such as cancer and various infectious, cardiovascular, and neurodegenerative diseases. View the Webinar

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网络研讨会 | 外泌体研究中的转化应用：从生物标志物发现到药物递送

外泌体——能够携带包括蛋白质和 microRNA 在内的多种生物货物的小型膜衍生细胞外囊泡——已在广泛的生物体液中被发现，并且似乎主要参与细胞间通讯。它们的自然特性使它们特别适合研究和临床应用，包括作为疾病和内在生物活性的生物标志物。事实上，外泌体已被假定为介导肿瘤与其周围环境之间发生的生物串扰，从而将这些肿瘤推向转移状态。此外，外泌体被选为一种治疗方式，并已通过其亲本细胞进行修改，以在其表面表达靶向部分或标记标签。它们还可以被操纵来携带可用于治疗多种疾病的药物制剂，例如癌症和各种感染性疾病、心血管疾病和神经退行性疾病。查看网络研讨会