One antibody for all and all antibodies for one Antibodies against related flavi-viruses such as dengue (DENV) and West Nile (WNV) can cross-react with Zika virus (ZIKV) and could thereby increase disease severity. Bardina et al. tested whether DENV and WNV antibodies from humans, or even yellow fever vaccination, could enhance ZIKV infection. In a mouse model, low titers of DENV and WNV antibodies enhanced ZIKV viremia, especially in the spinal cord and testes, whereas high titers remained protective. Generally, WNV antibodies were less disease-enhancing than DENV antibodies, and, in macaques, yellow fever vaccination had very little effect. Science, this issue p. 175 Antibodies against dengue and West Nile viruses cross-react with anti–Zika virus antibodies to enhance infection and fever in mice. Zika virus (ZIKV) is spreading rapidly into regions around the world where other flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV), are endemic. Antibody-dependent enhancement has been implicated in more severe forms of flavivirus disease, but whether this also applies to ZIKV infection is unclear. Using convalescent plasma from DENV- and WNV-infected individuals, we found substantial enhancement of ZIKV infection in vitro that was mediated through immunoglobulin G engagement of Fcγ receptors. Administration of DENV- or WNV-convalescent plasma into ZIKV-susceptible mice resulted in increased morbidity—including fever, viremia, and viral loads in spinal cord and testes—and increased mortality. Antibody-dependent enhancement may explain the severe disease manifestations associated with recent ZIKV outbreaks and highlights the need to exert great caution when designing flavivirus vaccines.

中文翻译：

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预先存在的抗黄病毒免疫力增强寨卡病毒的发病机制


一种抗体适用于所有病毒，所有抗体适用于一种针对登革热 (DENV) 和西尼罗河 (WNV) 等相关黄病毒的抗体可以与寨卡病毒 (ZIKV) 发生交叉反应，从而增加疾病的严重程度。巴迪纳等人。测试了来自人类的 DENV 和 WNV 抗体，甚至黄热病疫苗接种是否可以增强 ZIKV 感染。在小鼠模型中，低滴度的 DENV 和 WNV 抗体增强了 ZIKV 病毒血症，尤其是在脊髓和睾丸中，而高滴度的抗体仍具有保护作用。一般来说，西尼罗河病毒抗体比登革热病毒抗体对疾病的增强作用较小，而且对于猕猴来说，黄热病疫苗接种的效果非常小。科学，本期第 14 页。 175 抗登革热和西尼罗河病毒的抗体与抗寨卡病毒抗体发生交叉反应，从而增强小鼠的感染和发烧。寨卡病毒（ZIKV）正在迅速传播到世界各地其他黄病毒（例如登革热病毒（DENV）和西尼罗河病毒（WNV））流行的地区。抗体依赖性增强与更严重的黄病毒病有关，但这是否也适用于 ZIKV 感染尚不清楚。使用 DENV 和 WNV 感染者的恢复期血浆，我们发现 ZIKV 感染在体外显着增强，这是通过免疫球蛋白 G 与 Fcγ 受体的结合介导的。对 ZIKV 易感小鼠注射 DENV 或 WNV 恢复期血浆会导致发病率增加（包括发烧、病毒血症以及脊髓和睾丸中的病毒载量）以及死亡率增加。抗体依赖性增强可以解释与最近 ZIKV 爆发相关的严重疾病表现，并强调在设计黄病毒疫苗时需要非常谨慎。