Cell Biology Mycobacterium tuberculosis , the bacterium that causes tuberculosis (TB), mainly grows within host cells. Lerner et al. studied the lifestyle of M. tuberculosis within human macrophages by inspecting them with a combination of live-cell imaging, correlative light and electron microscopy, and single-cell analysis. After infection, some of the macrophages became necrotic and had damaged plasma membranes, although they still supported mycobacterial proliferation. Indeed, inhibiting necrosis compromised the macrophages' ability to support mycobacterium replication. Eventually, such cells ruptured to release progeny mycobacteria to infect new host cells. The ability of this microbe to exploit necrotic macrophages as a nutrient-rich haven isolated from host defenses likely contributes to its success in resisting antimycobacterial therapies. J. Cell Biol. 216 , 583 (2017).

中文翻译：

---

结核病利用僵尸细胞

细胞生物学 结核分枝杆菌是导致结核病 (TB) 的细菌，主要在宿主细胞内生长。勒纳等人。通过结合活细胞成像、相关光和电子显微镜以及单细胞分析对其进行检查，研究了人类巨噬细胞中结核分枝杆菌的生活方式。感染后，一些巨噬细胞坏死并破坏了质膜，尽管它们仍然支持分枝杆菌增殖。事实上，抑制坏死损害了巨噬细胞支持分枝杆菌复制的能力。最终，这些细胞破裂释放出后代分枝杆菌感染新的宿主细胞。这种微生物利用坏死巨噬细胞作为与宿主防御系统隔离的营养丰富的避风港的能力可能有助于其成功抵抗抗分枝杆菌疗法。J. 细胞生物学。216, 583 (2017)。