Structural Biology In bacteria, the transcription of DNA into mRNA by RNA polymerase is coupled to the translation of that mRNA into protein by the ribosome. How this coupling is achieved has been unclear. Kohler et al. show that RNA polymerase and the ribosome from Escherichia coli can form a so-called expressome complex. Electron microscopy structural analysis, together with functional experiments, revealed details of the coupled complex. The coupling could allow translation to prevent transcriptional pausing, backtracking, and termination. Science , this issue p. [194][1] [1]: /lookup/doi/10.1126/science.aal3059

中文翻译：

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偶联转录和翻译

结构生物学 在细菌中，通过 RNA 聚合酶将 DNA 转录为 mRNA 与通过核糖体将该 mRNA 翻译为蛋白质的过程相结合。这种耦合是如何实现的还不清楚。科勒等人。表明 RNA 聚合酶和来自大肠杆菌的核糖体可以形成所谓的表达组复合体。电子显微镜结构分析以及功能实验揭示了耦合复合物的细节。这种耦合可以允许翻译防止转录暂停、回溯和终止。科学，这个问题 p。[194][1][1]：/lookup/doi/10.1126/science.aal3059