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Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-04-06 00:00:00 , DOI: 10.1021/acs.accounts.7b00056
Gillian Houlihan 1 , Sebastian Arangundy-Franklin 1 , Philipp Holliger 1
Affiliation  

Nucleic acids are a distinct form of sequence-defined biopolymer. What sets them apart from other biopolymers such as polypeptides or polysaccharides is their unique capacity to encode, store, and propagate genetic information (molecular heredity). In nature, just two closely related nucleic acids, DNA and RNA, function as repositories and carriers of genetic information. They therefore are the molecular embodiment of biological information. This naturally leads to questions regarding the degree of variation from this seemingly ideal “Goldilocks” chemistry that would still be compatible with the fundamental property of molecular heredity.

中文翻译:

通过聚合酶工程探索遗传信息存储和传播的化学

核酸是序列定义的生物聚合物的一种独特形式。它们与多肽或多糖等其他生物聚合物的区别在于它们编码、存储和传播遗传信息(分子遗传)的独特能力。在自然界中,只有两种密切相关的核酸,DNA 和 RNA,充当遗传信息的储存库和载体。因此,它们是生物信息的分子体现。这自然会引发关于这种看似理想的“金发姑娘”化学的变异程度的问题,这种化学仍然与分子遗传的基本特性兼容。
更新日期:2017-04-06
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