Anaerobic bacteria can accumulate and proliferate within hypoxic and necrotic regions of solid tumours, stimulating inflammation and triggering an antitumour immune response. Zheng et al. have engineered an attenuated strain of Salmonella typhimurium to overexpress and secrete a heterologous bacterial flagellin (FlaB), which

中文翻译：

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癌症：基于细菌的免疫疗法

厌氧细菌可以在实体瘤的缺氧和坏死区域内积累和增殖，刺激炎症并触发抗肿瘤免疫反应。郑等。设计了减毒鼠伤寒沙门氏菌菌株以过表达和分泌异源细菌鞭毛蛋白（FlaB），