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PARP inhibitors plough on
Nature Reviews Drug Discovery ( IF 122.7 ) Pub Date : 2017-03-30 , DOI: 10.1038/nrd.2017.61
Asher Mullard

New clinical data for AstraZeneca's first-in-class poly(ADP-ribose) polymerase (PARP) inhibitor olaparib has raised the bar for a bevy of would-be competitors.The FDA granted accelerated approval to olaparib in 2014 for fourth-line treatment of BRCA-mutated ovarian cancer, but the drug came under pressure last

中文翻译:

PARP抑制剂不断涌现

阿斯利康一流的聚(ADP-核糖)聚合酶(PARP)抑制剂olaparib的新临床数据提高了一系列潜在竞争对手的门槛.2014年,FDA批准了olaparib的加速批准,用于olaparib的四线治疗BRCA突变的卵巢癌,但该药最后受到压力
更新日期:2017-04-11
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