Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis,Chemical Reviews

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Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-04-04 00:00:00 , DOI: 10.1021/acs.chemrev.6b00621
Abraham J Waldman ₁ , Tai L Ng ₁ , Peng Wang ₁ , Emily P Balskus ₁

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Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X, where X = N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and diversity of these structural motifs has captured the interest of synthetic and biological chemists alike. Functional groups containing X–X bonds are found in all major classes of natural products and often impart significant biological activity. This review presents our current understanding of the biosynthetic logic and enzymatic chemistry involved in the construction of X–X bond containing functional groups within natural products. Elucidating and characterizing biosynthetic pathways that generate X–X bonds could both provide tools for biocatalysis and synthetic biology, as well as guide efforts to uncover new natural products containing these structural features.

中文翻译：

天然产物生物合成中杂原子-杂原子键的形成

含有具有杂原子-杂原子键（X-X，其中 X = N、O、S 和 P）的官能团的天然产物是一小类但有趣的代谢物。这些结构基序的反应性和多样性引起了合成化学家和生物化学家的兴趣。含有 X-X 键的官能团存在于所有主要类别的天然产物中，并且通常具有显着的生物活性。这篇综述介绍了我们目前对天然产物中含有官能团的 X-X 键构建所涉及的生物合成逻辑和酶化学的理解。阐明和表征产生 X-X 键的生物合成途径既可以为生物催化和合成生物学提供工具，也可以指导发现含有这些结构特征的新天然产物的努力。

更新日期：2017-04-04

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