Pd/Cu-catalyzed dual C-H bond carbonylation towards the synthesis of fluorazones,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Pd/Cu-catalyzed dual C-H bond carbonylation towards the synthesis of fluorazones
Chemical Communications ( IF 4.3 ) Pub Date : 2017-03-24 00:00:00 , DOI: 10.1039/c7cc01707c
Fan Liao _{1,

2,

3,

4} , Renyi Shi _{4,

5,

6,

7,

8} , Yuchen Sha _{4,

5,

6,

7,

8} , Jianhui Xia _{1,

2,

3,

4} , Weilin Liao _{1,

2,

3,

4} , Aiwen Lei _{1,

2,

3,

4,

5}

Affiliation

Pd catalyzed oxidative dual C-H bond activation/carbonylation still remains a great challenge due to the generation of by-products via C-C bond formation. Herein, we developed a straightforward Pd/Cu-catalyzed oxidative dual C-H bond carbonylation process to access biologically and pharmaceutically important fluorazones from easily available N-aryl pyrroles and CO utilizing O₂ as the terminal oxidant.

中文翻译：

Pd / Cu催化的双CH键羰基化对氟氮酮的合成

由于经由CC键形成的副产物的生成，Pd催化的氧化性双CH键活化/羰基化仍然是一个巨大的挑战。本文中，我们开发了一种简单的Pd / Cu催化的氧化双CH键羰基化羰基化工艺，以利用O ₂作为末端氧化剂从易于获得的N-芳基吡咯和CO中获得生物学上和药学上重要的氟氮酮。

更新日期：2017-04-06

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11