Genome editing has emerged as an attractive approach to therapeutically manipulate gene expression. Here, Anderson and colleagues provide an overview of genome-editing platforms, focusing on the methods and challenges of intracellular biomacromolecule delivery. Preclinical and clinical trials involving genome-editing technologies are also discussed.

中文翻译：

---

基因组编辑的交付技术

基因组编辑已经成为治疗性控制基因表达的一种有吸引力的方法。在这里，Anderson及其同事对基因组编辑平台进行了概述，重点介绍了细胞内生物大分子递送的方法和挑战。还讨论了涉及基因组编辑技术的临床前和临床试验。