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Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance
Nature Reviews Drug Discovery ( IF 122.7 ) Pub Date : 2017-03-24 00:00:00 , DOI: 10.1038/nrd.2017.23
Seth W. Dickey , Gordon Y. C. Cheung , Michael Otto

Efforts to combat bacterial infections by targeting virulence factors are gaining traction, fuelled by the potential to circumvent the development of antibacterial resistance and recent landmark approvals of antivirulence drugs. Here, Otto and colleagues examine the antivirulence drugs in development, highlighting the most promising targets and strategies, as well as caveats to using this approach.

中文翻译:

各种针对臭虫的药物:抗药性时代的抗病毒策略

通过靶向毒力因子来对抗细菌感染的努力正受到越来越多的关注,这是由于有可能规避抗菌素耐药性的发展以及抗毒药的最新里程碑式批准。在这里,Otto及其同事检查了开发中的抗毒药物,重点介绍了最有希望的目标和策略,以及使用此方法的注意事项。
更新日期:2017-04-11
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