RNA Editing Differences occur between nucleotides encoded within DNA and the RNAs transcribed from these sequences. Such RNA editing can lead to changes in the amino acid composition of resulting proteins, and the removal of editing can have pathological consequences. Examining the occurrence of A-to-I editing in coding and noncoding RNA transcripts in 13 Drosophila species, Zhang et al. recorded the origin, loss, and maintenance of edited sites across the species. They found that editing can affect gene expression and that sites in both coding and noncoding sequences could be under evolutionary selection to maintain editing. In addition, RNA editing in the 3′ untranslated region of genes may contribute to mRNA degradation and may be a mechanism by which transcript levels are regulated. PLOS Genet. 13 , e1006563 (2017).

中文翻译：

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编辑过的 RNA 转录本的进化

RNA 编辑 DNA 内编码的核苷酸与从这些序列转录的 RNA 之间存在差异。这种 RNA 编辑会导致产生的蛋白质的氨基酸组成发生变化，而删除编辑会产生病理后果。Zhang 等人检查了 13 种果蝇的编码和非编码 RNA 转录本中 A-to-I 编辑的发生。记录了整个物种中编辑站点的起源、丢失和维护。他们发现编辑会影响基因表达，编码和非编码序列中的位点可能处于进化选择之下以维持编辑。此外，基因 3' 非翻译区中的 RNA 编辑可能会导致 mRNA 降解，并且可能是调节转录水平的一种机制。PLOS 基因。13 , e1006563 (2017)。