Signal Transduction Notch proteins are transmembrane receptors that are important in the regulation of cell fate. They are unusual in that their ligands are membrane-bound on adjacent cells. Luca et al. provide insights into the signaling interactions between Notch and its various ligands. The crystal structure of Notch complexed with a variant of its ligand Jagged1 revealed the interaction of Notch domains containing O -linked glycans with particular domains in Jagged1. Measurements of the effects of various forces on the interaction showed that application of force increases the lifetime of bonds between receptor and ligand. The studies help explain how low-affinity interactions of Notch with its ligands can lead to signaling and indicate that forces may differentially affect Notch-ligand interactions. Science , this issue p. [1320][1] [1]: /lookup/doi/10.1126/science.aaf9739

中文翻译：

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拉扯 Notch 受体调节信号

信号转导 Notch 蛋白是跨膜受体，在调节细胞命运中很重要。它们的不同寻常之处在于它们的配体与相邻细胞膜结合。卢卡等人。深入了解 Notch 及其各种配体之间的信号相互作用。Notch 的晶体结构与其配体 Jagged1 的变体复合，揭示了含有 O 连接聚糖的 Notch 域与 Jagged1 中特定域的相互作用。各种力对相互作用影响的测量表明，力的应用增加了受体和配体之间键的寿命。这些研究有助于解释 Notch 与其配体的低亲和力相互作用如何导致信号传导，并表明力可能会不同地影响 Notch-配体相互作用。科学，这个问题 p。[1320][1][1]：