Ion Channels N -methyl-d-aspartate receptors (NMDARs) are heterotetrameric ion channels that initiate chemical and electrical signals in postsynaptic cells. They play key roles in brain development and function and are the targets of drugs for treating neurological disorders such as schizophrenia, depression, and epilepsy. For the channel to open, it must bind glutamate and glycine and release a blocking magnesium ion. Most NMDARs have three different subunits that bind glycine and glutamine, but structural studies have focused on tetramers of only two subunits. Lu et al. determined the structure of triheteromeric NMDAR. The structural studies show how having three different subunits modifies receptor symmetry and subunit interactions and increases the complexity of receptor regulation. Science , this issue p. [eaal3729][1] [1]: /lookup/doi/10.1126/science.aal3729

中文翻译：

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增加不对称受体的复杂性

离子通道 N-甲基-d-天冬氨酸受体 (NMDAR) 是异源四聚体离子通道，可在突触后细胞中启动化学和电信号。它们在大脑发育和功能中发挥关键作用，是治疗精神分裂症、抑郁症和癫痫等神经系统疾病的药物靶点。要打开通道，它必须结合谷氨酸和甘氨酸并释放阻断镁离子。大多数 NMDAR 具有三个不同的亚基，可结合甘氨酸和谷氨酰胺，但结构研究仅集中在两个亚基的四聚体上。卢等人。确定了三聚体 NMDAR 的结构。结构研究表明具有三个不同的亚基如何改变受体对称性和亚基相互作用，并增加受体调节的复杂性。科学，这个问题 p。[eaal3729][1][1]：/lookup/doi/10。