Immunological Memory Liver-resident T cells defend against infections such as malaria and hepatitis B virus. McNamara et al. found that liver-resident CD8+ T cells up-regulate LFA-1 and that LFA-1–ICAM-1 interactions are critical for T cell patrolling of the hepatic sinusoids. Moreover, in the absence of LFA-1, CD8+ T cells did not form liver-resident memory populations in mice, even after the animals were infected with the parasite that causes malaria ( Plasmodium ) or lymphocytic choriomeningitis virus. Thus, LFA-1 expression acts as a sort of invisible fence, allowing the liver-resident memory T cells free rein within the boundaries of the liver. Sci. Immunol. 2 , eaaj1996 (2017).

中文翻译：

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帮助 T 细胞在肝脏中感到宾至如归

免疫记忆 肝脏驻留 T 细胞防御疟疾和乙型肝炎病毒等感染。麦克纳马拉等人。发现肝脏驻留的 CD8+ T 细胞上调 LFA-1 并且 LFA-1-ICAM-1 相互作用对于肝窦的 T 细胞巡逻至关重要。此外，在没有 LFA-1 的情况下，CD8+ T 细胞不会在小鼠体内形成肝脏常驻记忆群体，即使在动物感染了引起疟疾的寄生虫（疟原虫）或淋巴细胞脉络丛脑膜炎病毒之后也是如此。因此，LFA-1 表达就像一种无形的栅栏，允许肝脏驻留记忆 T 细胞在肝脏边界内自由发挥作用。科学。免疫学。2、eaaj1996 (2017)。