Nanoengineering of Core–Shell Magnetic Mesoporous Microspheres with Tunable Surface Roughness,Journal of the American Chemical Society

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Nanoengineering of Core–Shell Magnetic Mesoporous Microspheres with Tunable Surface Roughness
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-03-22 , DOI: 10.1021/jacs.7b01464
Qin Yue ₁ , Yu Zhang ₁ , Yongjian Jiang ₂ , Jialuo Li ₁ , Hongwei Zhang ₃ , Chengzhong Yu ₃ , Ahmed A. Elzatahry ₄ , Abdulaziz Alghamdi ₅ , Yonghui Deng _{1,

6} , Dongyuan Zhao ₁

Affiliation

Functional core-shell mesoporous microspheres with integrated functions, controlled structure, and surface properties and morphologies have received increasing attention due to their excellent physicochemical properties. Herein, core-shell magnetic mesoporous materials with cauliflower-like morphology and tunable surface roughness have been synthesized through a kinetics-controlled interface co-assembly and deposition of mesostructured nanocomposites on Fe3O4@RF microspheres (RF refers to resorcinol formaldehyde resin). The obtained microspheres, synthesized via this interface nanoengineering method, possess well-defined sandwich structure with a tunable rough morphology, uniform size (560-1000 nm), perpendicularly aligned mesopores (∼5.7 nm) in the outer shell, RF-protected magnetic responsive core, high surface area up to 382 m2/g, and large pore volume of 0.66 cm3/g. As a result of the unique surface features and magnetic properties, these microspheres exhibit excellent performance in stabilizing and oxygen-free manipulating aqueous solutions in petroleum ether by a magnetic field. They also exhibit superior cell uptake properties compared with traditional smooth core-shell magnetic mesoporous silica microspheres, opening up the possible applications in fast drug delivery in cancer therapy.

中文翻译：

具有可调表面粗糙度的核壳磁性介孔微球的纳米工程

具有综合功能、可控结构、表面性质和形态的功能性核壳介孔微球由于其优异的理化性质而受到越来越多的关注。在此，通过动力学控制的界面共组装和介孔结构纳米复合材料在 Fe3O4@RF 微球（RF 指间苯二酚甲醛树脂）上的沉积，合成了具有花椰菜状形态和可调表面粗糙度的核壳磁性介孔材料。通过这种界面纳米工程方法合成的微球具有明确的夹层结构，具有可调的粗糙形态、均匀的尺寸（560-1000 nm）、外壳中垂直排列的介孔（~5.7 nm）、射频保护的磁响应核心，高表面积高达 382 平方米/克，和0.66 cm3/g的大孔体积。由于独特的表面特征和磁性，这些微球在通过磁场稳定和无氧操纵石油醚中的水溶液方面表现出优异的性能。与传统的光滑核壳磁性介孔二氧化硅微球相比，它们还表现出优异的细胞吸收特性，开辟了癌症治疗中快速药物递送的可能应用。

更新日期：2017-03-22

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