Convergent Chemical Synthesis of Histone H3 Protein for Site-Specific Acetylation at Lys56 and Ubiquitination at Lys122,Chemical Communications

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Convergent Chemical Synthesis of Histone H3 Protein for Site-Specific Acetylation at Lys56 and Ubiquitination at Lys122
Chemical Communications ( IF 4.9 ) Pub Date : 2017-03-21 00:00:00 , DOI: 10.1039/c7cc01721a
Yun-Kun Qi _{1,

2,

3,

4,

5} , Qiao-Qiao He _{1,

2,

3,

4,

5} , Hua-Song Ai _{1,

2,

3,

4,

5} , Jing Guo _{1,

2,

3,

4,

5} , Jia-Bin Li _{1,

2,

3,

4,

5}

Affiliation

Deposition of (H3-H4)₂ tetramers is believed to be the critical step in nucleosome assembly. Site-specific acetylation and ubiquitination of histone H3 are speculated to synergistically facilitate the formation and deposition...

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