Changes in glutamate signalling have been implicated in major depression, and ketamine, which was recently found to act as a rapid-acting antidepressant, affects glutamate signalling in several ways. Murrough and colleagues give an overview of the development of glutamate-signalling modulators for depression and examine studies on the mechanisms of these agents.

中文翻译：

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针对抑郁症的谷氨酸信号：进展和前景

谷氨酸信号的变化与重度抑郁有关，最近发现的氯胺酮起着快速作用的抗抑郁药的作用，它以多种方式影响谷氨酸信号。Murrough及其同事概述了用于抑郁症的谷氨酸信号调节剂的开发，并研究了有关这些药物作用机理的研究。