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Human α-Defensin 6: A Small Peptide That Self-Assembles and Protects the Host by Entangling Microbes
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-03-15 00:00:00 , DOI: 10.1021/acs.accounts.6b00653 Phoom Chairatana 1 , Elizabeth M. Nolan 1
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-03-15 00:00:00 , DOI: 10.1021/acs.accounts.6b00653 Phoom Chairatana 1 , Elizabeth M. Nolan 1
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Human α-defensin 6 (HD6) is a 32-residue cysteine-rich peptide that contributes to innate immunity by protecting the host at mucosal sites. This peptide is produced in small intestinal Paneth cells, stored as an 81-residue precursor peptide named proHD6 in granules, and released into the lumen. One unusual feature of HD6 is that it lacks the broad-spectrum antimicrobial activity observed for other human α-defensins, including the Paneth cell peptide human α-defensin 5 (HD5). HD6 exhibits unprecedented self-assembly properties, which confer an unusual host-defense function. HD6 monomers self-assemble into higher-order oligomers termed “nanonets”, which entrap microbes and prevent invasive gastrointestinal pathogens such as Salmonella enterica serovar Typhimurium and Listeria monocytogenes from entering host cells. One possible advantage of this host-defense mechanism is that HD6 helps to keep microbes in the lumen such that they can be excreted or attacked by other components of the immune system, such as recruited neutrophils.
中文翻译：
人α-防御素6：通过纠缠微生物自组装并保护宿主的小肽
人α-防御素6（HD6）是32个残基的富含半胱氨酸的肽，可通过在粘膜部位保护宿主来促进先天免疫。该肽在小肠Paneth细胞中产生，以81个残基的前体肽proHD6的形式存储在颗粒中，然后释放到管腔中。HD6的一个不寻常特征是，它缺乏对其他人类α-防御素（包括Paneth细胞肽人类α-防御素5（HD5））观察到的广谱抗菌活性。HD6具有空前的自组装特性，赋予了不寻常的主机防御功能。HD6单体可自组装成称为“ nanonets”的高级低聚物，可捕获微生物并预防肠胃沙门氏菌血清型鼠伤寒沙门氏菌和单核细胞增生性李斯特菌等侵入性胃肠道病原体从进入宿主细胞。这种宿主防御机制的一个可能优势是，HD6有助于将微生物保留在管腔中，从而使它们可以被免疫系统的其他组件（例如募集的嗜中性白细胞）排泄或攻击。
更新日期：2017-03-15
中文翻译：
人α-防御素6：通过纠缠微生物自组装并保护宿主的小肽
人α-防御素6（HD6）是32个残基的富含半胱氨酸的肽，可通过在粘膜部位保护宿主来促进先天免疫。该肽在小肠Paneth细胞中产生，以81个残基的前体肽proHD6的形式存储在颗粒中，然后释放到管腔中。HD6的一个不寻常特征是，它缺乏对其他人类α-防御素（包括Paneth细胞肽人类α-防御素5（HD5））观察到的广谱抗菌活性。HD6具有空前的自组装特性，赋予了不寻常的主机防御功能。HD6单体可自组装成称为“ nanonets”的高级低聚物，可捕获微生物并预防肠胃沙门氏菌血清型鼠伤寒沙门氏菌和单核细胞增生性李斯特菌等侵入性胃肠道病原体从进入宿主细胞。这种宿主防御机制的一个可能优势是，HD6有助于将微生物保留在管腔中，从而使它们可以被免疫系统的其他组件（例如募集的嗜中性白细胞）排泄或攻击。
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