Hydrogen sulfide (H₂S), together with nitric oxide (NO) and carbon monoxide (CO), belongs to the gasotransmitter family and plays important roles in mammals as a signaling molecule. Many studies have also shown the various therapeutic effects of H₂S, which include protection against myocardial ischemia injury, cytoprotection against oxidative stress, mediation of neurotransmission, inhibition of insulin signaling, regulation of inflammation, inhibition of the hypoxia‐inducible pathway, and dilation of blood vessels. One major challenge in the development of H₂S‐based therapeutics is its delivery. In this manuscript, we assess the various drug delivery strategies in the context of being used research tools and eventual developability as therapeutic agents.

中文翻译：

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走向以硫化氢为基础的治疗方法：关键的药物递送和可开发性问题

硫化氢（H ₂ S）与一氧化氮（NO）和一氧化碳（CO）一起属于气体传输器家族，并在哺乳动物中作为信号分子发挥重要作用。许多研究还显示了H ₂ S的各种治疗作用，包括对心肌缺血的保护作用，对氧化应激的细胞保护作用，神经传递的介导作用，对胰岛素信号传导的抑制作用，对炎症的调节，对低氧诱导途径的抑制作用以及扩张作用。血管。基于H ₂ S的疗法的发展中的一项主要挑战是其交付。在本手稿中，我们在被使用的研究工具和最终可作为治疗剂的可开发性的背景下评估了各种药物递送策略。