Isotope Tracers To Study the Environmental Fate and Bioaccumulation of Metal-Containing Engineered Nanoparticles: Techniques and Applications,Chemical Reviews

当前位置： X-MOL 学术 › Chem. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Isotope Tracers To Study the Environmental Fate and Bioaccumulation of Metal-Containing Engineered Nanoparticles: Techniques and Applications
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-02-17 00:00:00 , DOI: 10.1021/acs.chemrev.6b00693
Yongguang Yin _{1,

2} , Zhiqiang Tan ₁ , Ligang Hu ₁ , Sujuan Yu ₁ , Jingfu Liu ₁ , Guibin Jiang ₁

Affiliation

The rapidly growing applicability of metal-containing engineered nanoparticles (MENPs) has made their environmental fate, biouptake, and transformation important research topics. However, considering the relatively low concentration of MENPs and the high concentration of background metals in the environment and in organisms, tracking the fate of MENPs in environment-related scenarios remains a challenge. Intrinsic labeling of MENPs with radioactive or stable isotopes is a useful tool for the highly sensitive and selective detection of MENPs in the environment and organisms, thus enabling tracing of their transformation, uptake, distribution, and clearance. In this review, we focus on radioactive/stable isotope labeling of MENPs for their environmental and biological tracing. We summarize the advantages of intrinsic radioactive/stable isotopes for MENP labeling and discuss the considerations in labeling isotope selection and preparation of labeled MENPs, as well as exposure routes and detection of labeled MENPs. In addition, current practice in the use of radioactive/stable isotope labeling of MENPs to study their environmental fate and bioaccumulation is reviewed. Future perspectives and potential applications are also discussed, including imaging techniques for radioactive- and stable-isotope-labeled MENPs, hyphenated multistable isotope tracers with speciation analysis, and isotope fractionation as a MENP tracer. It is expected that this critical review could provide the necessary background information to further advance the applications of isotope tracers to study the environmental fate and bioaccumulation of MENPs.

中文翻译：

同位素示踪剂研究含金属工程纳米粒子的环境命运和生物富集：技术和应用

含金属的工程纳米颗粒（MENP）的迅速增长的适用性已使其环境命运，生物吸收和转化成为重要的研究课题。但是，考虑到MENP的相对较低浓度以及环境和生物中背景金属的高浓度，在与环境有关的情况下跟踪MENP的命运仍然是一个挑战。用放射性或稳定同位素对MENP进行内在标记是一种非常有用的工具，可用于高度敏感和选择性地检测环境和生物体中的MENP，从而能够追踪其转化，吸收，分布和清除情况。在这篇综述中，我们专注于MENP的放射性/稳定同位素标记，以对其进行环境和生物追踪。我们总结了固有放射性/稳定同位素用于MENP标记的优势，并讨论了在标记同位素选择和标记MENP的制备以及标记MENP的暴露途径和检测中的注意事项。另外，综述了目前使用MENPs进行放射性/稳定同位素标记研究其环境命运和生物积累的实践。还讨论了未来的前景和潜在的应用，包括放射性和稳定同位素标记的MENP的成像技术，具有形态分析的联用多稳态同位素示踪剂，以及作为MENP示踪剂的同位素分馏。

更新日期：2017-02-17

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11