Nanodiscs in Membrane Biochemistry and Biophysics,Chemical Reviews

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Nanodiscs in Membrane Biochemistry and Biophysics
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-02-08 00:00:00 , DOI: 10.1021/acs.chemrev.6b00690
Ilia G Denisov ₁ , Stephen G Sligar ₁

Affiliation

Membrane proteins play a most important part in metabolism, signaling, cell motility, transport, development, and many other biochemical and biophysical processes which constitute fundamentals of life on the molecular level. Detailed understanding of these processes is necessary for the progress of life sciences and biomedical applications. Nanodiscs provide a new and powerful tool for a broad spectrum of biochemical and biophysical studies of membrane proteins and are commonly acknowledged as an optimal membrane mimetic system that provides control over size, composition, and specific functional modifications on the nanometer scale. In this review we attempted to combine a comprehensive list of various applications of nanodisc technology with systematic analysis of the most attractive features of this system and advantages provided by nanodiscs for structural and mechanistic studies of membrane proteins.

中文翻译：

膜生物化学和生物物理学中的纳米圆盘

膜蛋白在新陈代谢、信号传导、细胞运动、运输、发育以及许多其他生物化学和生物物理过程中发挥着最重要的作用，这些过程在分子水平上构成了生命的基础。详细了解这些过程对于生命科学和生物医学应用的进步是必要的。纳米圆盘为膜蛋白的广泛生化和生物物理研究提供了一种新的强大工具，并且被普遍认为是一种最佳的膜模拟系统，可以在纳米尺度上控制尺寸、组成和特定功能修饰。在这篇综述中，我们试图将纳米圆盘技术的各种应用的综合列表与该系统最有吸引力的特征的系统分析以及纳米圆盘为膜蛋白的结构和机制研究提供的优势结合起来。

更新日期：2017-02-08

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