C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential,Chemical Reviews

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C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-01-25 00:00:00 , DOI: 10.1021/acs.chemrev.6b00475
Éva Bokor ₁ , Sándor Kun ₁ , David Goyard ₂ , Marietta Tóth ₁ , Jean-Pierre Praly ₂ , Sébastien Vidal ₂ , László Somsák ₁

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This Review summarizes close to 500 primary publications and surveys published since 2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het)arenes. A classification of the preparative routes to these synthetic targets according to methodologies and compound categories is provided. Several of these compounds, regardless of their natural or synthetic origin, display antidiabetic properties due to enzyme inhibition (glycogen phosphorylase, protein tyrosine phosphatase 1B) or by inhibiting renal sodium-dependent glucose cotransporter 2 (SGLT2). The latter class of synthetic inhibitors, very recently approved as antihyperglycemic drugs, opens new perspectives in the pharmacological treatment of type 2 diabetes. Various compounds with the C-glycopyranosyl (het)arene motif were subjected to biological studies displaying among others antioxidant, antiviral, antibiotic, antiadhesive, cytotoxic, and glycoenzyme inhibitory effects.

中文翻译：

C -Glycopyranosyl芳烃和戊烯：合成方法和生物活性集中在抗糖尿病的潜力。

这篇综述总结了自2000年以来出版的近500篇有关C-糖基核糖基（het）芳烃的合成和多种生物活性的调查报告。提供了根据方法和化合物类别对制备这些合成靶标的制备途径的分类。这些化合物中的几种，无论其天然或合成来源，均由于酶抑制作用（糖原磷酸化酶，蛋白质酪氨酸磷酸酶1B）或抑制肾钠依赖性葡萄糖共转运蛋白2（SGLT2）而显示出抗糖尿病特性。后者的合成抑制剂，最近被批准用作降血糖药，为2型糖尿病的药物治疗开辟了新的前景。各种化合物与C-glycopyranosyl（het）arene主题经过了生物学研究，显示出抗氧化剂，抗病毒剂，抗生素，抗粘连剂，细胞毒性和糖酵素抑制作用。

更新日期：2017-01-25

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