This review comprehensively covers the most recent achievements (from 2013) in the successful integration of nanomaterials in the field of glycomics. The first part of the paper addresses the beneficial properties of nanomaterials for the construction of biosensors, bioanalytical devices, and protocols for the detection of various analytes, including viruses and whole cells, together with their key characteristics. The second part of the review focuses on the application of nanomaterials integrated with glycans for various biomedical applications, that is, vaccines against viral and bacterial infections and cancer cells, as therapeutic agents, for in vivo imaging and nuclear magnetic resonance imaging, and for selective drug delivery. The final part of the review describes various ways in which glycan enrichment can be effectively done using nanomaterials, molecularly imprinted polymers with polymer thickness controlled at the nanoscale, with a subsequent analysis of glycans by mass spectrometry. A short section describing an active glycoprofiling by microengines (microrockets) is covered as well.

中文翻译：

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糖组学中的纳米技术：在诊断、治疗、成像和分离过程中的应用

本综述全面涵盖了纳米材料在糖组学领域成功整合的最新成就（自 2013 年起）。本文的第一部分介绍了纳米材料对于构建生物传感器、生物分析设备和检测各种分析物（包括病毒和全细胞）的方案的有益特性及其关键特性。综述的第二部分重点关注与聚糖集成的纳米材料在各种生物医学应用中的应用，即针对病毒和细菌感染和癌细胞的疫苗，作为治疗剂，用于体内成像和核磁共振成像，以及用于选择性药物输送。综述的最后部分描述了使用纳米材料、聚合物厚度控制在纳米级的分子印迹聚合物有效地富集聚糖的各种方法，并随后通过质谱法对聚糖进行分析。还介绍了描述微引擎（微火箭）主动糖谱分析的一小部分。