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1) Developing fluorescent/chemiluminescent sensors for molecular detection and imaging of reactive oxygen species, lipids, DNA, metabolites and enzymes in living cells to study redox biology and human diseases. 2) Developing new molecular probes for proteins and nucleic acids to investigate epigenetic changes in relation to their functions. 3) Developing synthetic ion transporters and exploring their biological applications in eradicating cancer stem cells and drug-resistant bacteria.