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158.        S. Ye, J. J. Hu, Q. A. Zhao, D. Yang*. Fluorescent probes for in vitro and in vivo quantification of hydrogen peroxide. Chem. Sci. 202011, 11989–11997 (Highlighted as Front Cover).


157.        S.-Y. Dai, D. Yang*. A Visible and Near-Infrared Light Activatable Diazo-Coumarin Probe for Fluorogenic Protein Labeling in Living Cells. J. Am. Chem. Soc. 2020, 142, 17156–17166 (Highlighted as Supplementary Cover).

156.        S. Ye, N. Hananya, O. Green, H.-S. Chen, A. Q. Zhao, J.-G. Shen, D. Shabat*, D. Yang*. A Highly Selective and Sensitive Chemiluminescent Probe for Real‐Time Monitoring of Hydrogen Peroxide in Cells and Animals. Angew. Chem. Int. Ed. 2020, 59, 1432614330.

155.        F.-F. Shen, S.-Y. Dai, N.-K. Wong, S. Deng, A. S.-T. Wong, D. Yang*. Mediating K+/H+ Transport on Organelle Membranes to Selectively Eradicate Cancer Stem Cells by a Small Molecule. J. Am. Chem. Soc. 2020,  142, 10769–10779 (Highlighted as Supplementary Cover).

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154.        X.-Y. Bai, B.-W. Yang, H.-S. Chen, J.-G. Shen, D. Yang*. HKOCl-4: A Rhodol-based Yellow Fluorescent Probe for Detection of Hypochlorous Acid in Living Cells and Tissues. Org. Chem. Front. 2020, 7, 993–996.

Graphical abstract: HKOCl-4: a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues

153.        X. Zhou, X. Ding, J.-G. Shen, D. Yang, L.G. Hudson, K.J. Liu*. Peroxynitrite contributes to arsenic-induced PARP-1 inhibition through ROS/RNS generation. Toxicol. Appl. Pharmacol. 2019, 378, 114602.

152.        B. Tsoi, S.-L. Wang, C. Gao, Y.-H. Luo, W.-T. Li, D. Yang, D.-P. Yang, J.-G. Shen*. Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury, Toxicol. Appl. Pharmacol. 2019, 377, 114613.

151.        W. Li, J. Feng, C. Gao, M. Wu, Q. Du, B. Tsoi, Q. Wang, D. Yang, J. Shen*. Nitration of Drp1 provokes mitophagy activation mediating neuronal injury in experimental autoimmune encephalomyelitis, Free Radic. Biol. Med. 2019, 143, 70-83.

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150.        X.-Y. Bai, K. K.-H. Ng, J. J. Hu, S. Ye, D. Yang*. Small Molecule-based Fluorescent Sensors for Selective Detection of Reactive Oxygen Species in Biological Systems. Annu. Rev. Biochem. 2019, 88, 605–633.

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149.        S. P. T. Yiu, K. F. Hui, C. K. Choi, R. Y. T. Kao, C. W. Ma, D. Yang, A. K. S. Chiang*. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers. Cancers 2018, 10, 505.

148.        M.-D. Li, N.-K. Wong, J. Xiao, R.-X. Zhu, L.-L. Wu, S. Y. Dai, F. Chen, G.-H. Huang, X.-Y. Bai, M. R. Geraskina, A. H. Winter, X.-B. Chen*, Y.-X. Liu, W.-H. Fang, D. Yang*, D. L. Phillips*. Dynamics of oxygen-independent photocleavage of blebbistatin as a one-photon blue or two-photon near infrared light-gated hydroxyl radical photocage. J. Am. Chem. Soc. 2018, 140, 15957–15968.

147.        S. Ye, J. J. Hu, D. Yang*. Tandem Payne/Dakin Reaction: A New Strategy for Hydrogen Peroxide Detection and Molecular Imaging. Angew. Chem. Int. Ed. 2018, 57, 10173 –10177. (Very Important Paper)

146.        W.-T. Li, H. Wu, C. Gao, D. Yang, D.-P. Yang, J.-G. Shen*. Radix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-derived Nitrative Damage. Front. Physiol. 2018, doi: 10.3389/fphys.2018.00864.

Frontiers | Radix Rehmanniae Extract Ameliorates Experimental ...

145.        X. Chen,  B. Zhou, T. Yan, H. Wu, J. Feng, H. Chen, C. Gao, T. Peng, D. Yang, J.-G. Shen*. Peroxynitrite Enhances Self-renewal, Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells through Activating HIF-1a and Wnt/ß-catenin Signaling Pathway. Free Radic. Biol. Med. 2018, 117, 158-167. doi: 10.1016/j.freeradbiomed.2018.02.011. Epub 2018 Feb 7.

Peroxynitrite enhances self-renewal, proliferation and neuronal ...

144.        H.-S. Chen, B.-H. Guan, X. Chen, X.-M. Chen, C.-M. Li, J.-H. Qiu, D. Yang, K.-J. Liu, S.-H. Qi, J.-G. Shen*.  Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO--MMP-9 Pathway. Transl. Stroke Res. 2018, 9, 515-529. Doi: 10.1007/s12975-017-0598-3.

Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic ...

143.        H. Tse, Q.-S. Gu, K.-H. Sze, I. K. Chu, R. Y.-T. Kao, K.-C. Lee, C.-W. Lam, D. Yang, S. S.-C. Tai, Y.-H. Ke, E. Chan, W.-M. Chan, J. Dai, S.-P. Leung, S.-Y. Leung, K.-Y. Yuen*. A Tricyclic Pyrrolobenzodiazepine Produced by Klebsiella oxytoca is Associated with Cytotoxicity in Antibiotic Associated Hemorrhagic Colitis. J. Biol. Chem. 2017, 292, 19503–19520.

142.        X.-Y. Bai, Y.-Y. Huang, M.-Y. Lu, D. Yang*. HKOH-1: A Highly Sensitive and Selective Fluorescent Probe for Detecting Endogenous Hydroxyl Radical in Living Cells. Angew. Chem. Int. Ed. 2017, 56, 12873 –12877.

HKOH‐1: A Highly Sensitive and Selective Fluorescent Probe for ...

141.        W. Du, Q.-S. Gu, Y. Li, Z.-Y. Lin, D. Yang*. Enantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides. Org. Lett. 2017, 19, 316−319.


140.        L. Ye, K.-Y. Lo, Q.-S. Gu, D. Yang*. Pd-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes: Access to Diverse N-Heterocycles. Org. Lett. 2017, 19, 308−311.

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139.        Q.-S. Gu, D. Yang*. Enantioselective Synthesis of (+)-Mitomycin K via Palladium-Catalyzed Oxidative Tandem Cyclization. Angew. Chem. Int. Ed. 2017, 56, 5886-5889.

Angewandte Chemie International Edition: Vol 56, No 21

138.        J. J. Hu, S. Ye, D. Yang*. Fluorescent Probes for HOCl Imaging. Isr. J. Chem. 2017, 57, 251 –258.

Fluorescent Probes for HOCl Imaging - Hu - 2017 - Israel Journal ...

137.        P.-Y. Liu, S.-T. Li, F.-F. Shen, W.-H. Ko*, X.-Q. Yao*,D. Yang*. A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells. Chem. Commun. 2016, 52, 7380-7383.

Graphical abstract: A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

136.        L. Gao, X.-M. Chen, T. Peng, D. Yang, Q. Wang, Z.-P. Lv, J.-G. Shen*. Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death. Free Rad. Biol. Med. 2016, 95, 209–215.

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135.        T. Peng, X.-M. Chen, L. Gao, T. Zhang, W. Wang, J.-G. Shen, D. Yang*. A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues. Chem. Sci. 2016, 7, 5407–5413.

A rationally designed rhodamine-based fluorescent probe for ...

134.        J. J. Hu, N.-K. Wong, M.-Y. Lu, X.-M. Chen, S. Ye, A. Q. Zhao, P. Gao, R. Y.-T. Kao, J.-G. Shen, D. Yang*. HKOCl-3: A fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and 96-well microplate assay.  Chem. Sci. 2016, 7, 2094 – 2099.

HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and ...

133.        J. J. Hu, N.-K. Wong, S. Ye, X.-M. Chen, M.-Y. Lu, A. Q. Zhao, Y.-H. Guo, A. C.-H. Ma, A. Y.-H. Leung, J.-G. Shen, D. Yang. Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo. J. Am. Chem. Soc. 2015, 137, 6837–6843.

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132.        Y. Hao, K. An, D.-W. Zhang, D. Yang. A Short Helix Formed by Cyclic b2,3-Aminoxy Peptides in Protic Solvents. Chem. Asian J. 2015, 10, 2126-2129.

131.        P. Di Tomo, S. Di Silvestre, V.G.P. Cordone, A. Giardinelli, B. Faricelli, C. Pipino, P. Lanuti, T. Peng, G. Formoso, D. Yang, A. Arduini, F. Chiarelli, A. Pandolfi, N. Di Pietro*. Centella Asiatica and Lipoic Acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women. Nutr. Metab. Cardiovasc. Dis. 2015, 25, 659‒666.

130.        Q. Zhao, Y. Ding, Z.-S. Deng, O.-Y. Lee, P. Gao, P. Chen, R. J. Rose, H. Zhao, Z.-H. Zhang, X.-P. Tao, A. J. R. Heck, R.Y.C. Kao, D. Yang*. Identification of Natural Products Triptolide, Celastrol and Withaferin A as Binding Ligands of Peroxiredoxin I. Chem. Sci. 2015, 6, 4124‒4130.

Graphical abstract: Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I

129.        Z.-L. Li, D. Yang. Construction of 9,10-syn-trans-Decalin Skeleton via Semipinacol Rearrangement: Asymmetric Synthesis of (+)-syn-Copalol and a Candelalide Analog. Tetrahedron Lett. Wasserman Special Issue. 2015, 56, 3667–3669.

128.        W. Du, Q.-S. Gu, Z.-L. Li, D. Yang*. Palladium(II)-Catalyzed Intramolecular Tandem Aminoalkylation via Divergent C(sp3)–H Functionalization. J. Am. Chem. Soc. 2015, 137, 1130–1135.

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127.        S. S.-W. Wong, R. Y.-T. Kao*, K.-Y. Yuen, Y. Wang, D. Yang, L. P. Samaranayake, C. J. Seneviratne*. In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections. PLoS One, 2014, 9, e85836.

126.        H.-Y. Zha, B. Shen, K.-H. Yau, S.-T. Li, X.-Q. Yao*, D. Yang*. A Small Synthetic Molecule Forms Selective Potassium Channels to Regulate Cell Membrane Potential and Blood Vessel Tone. Org. Biol. Chem. 2014, 12, 8174–8179.

125.        T. Peng, N.-K. Wong, X.-M. Chen, Y.-K. Chan, D. H.-H. Ho, Z.-N. Sun, J. J. Hu, J.-G. Shen, H. El-Nezami, D. Yang*. Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues. J. Am. Chem. Soc. 2014, 136, 11728–11734.

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124.        W. R. Zhang, K. T. Li, X. T. Zhu, D. Wu, W. Shang, X. F. Yuan, Z. L. Huang, M. Zheng, X. H. Wang, D. Yang, J. Liu, H. P. Cheng. Subsarcolemmal Mitochondrial Flashes Induced by Hypochlorous Acid Stimulation in Cardiac Myocytes. Free Radical Res. 2014, 48, 1085–1094.  

123.        J. J. Hu, N.-K. Wong, Q.-S. Gu, X.-Y. Bai, S. Ye, D. Yang. HKOCl-2 Series of Green BODIPY-Based Fluorescent Probes for Hypochlorous Acid Detection and Imaging in Live Cells. Org. Lett., 2014, 16, 3544–3547.

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122.        Z.-Y. Wang, W.-T. Wong, D. Yang*. Asymmetric Organocatalytic Synthesis of Dihydrodibenzofuran Species Based on a Dienamine Process. Org. Lett., 2013, 15, 4980–4983.

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121.        M. Xu, X. Chen, Y. Gu, T. Peng, D. Yang, R. Chang, K.F. So, K.J. Liu, J.-G. Shen. Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury. J Ethnopharmacol. 2013, 150, 116-124.

120.        D. Xing, D. Yang*. Pd(II)-Catalyzed Intramolecular 1,2-Aminoalkylation of Conjugated 1,3-Dienes for the Synthesis of Pyrrolizidines. Org. Lett., 2013, 15, 4370–4373.

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119.        D. Obal, S.J. Dai, R. Keith, N. Dimova, J. Kingery, Y.-T. Zheng, J. Zweier, M. Velayutham, S. D. Prabhu, Q.-H. Li, D. Conklin, D. Yang, A. Bhatnagar, R. Bolli, G. Rokosh. Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion. Basic Res. Cardiol. 2012, 107, 305.

118.        K.-H. Yau, J. C.-W. Mak, S. W.-S. Leung, D. Yang, P. M. Vanhoutte*. A Synthetic Chloride Channel Relaxes Airway Smooth Muscle of the Rat. PLoS One, 2012, 7(9), e45340.

117.        B. Ma, C. Yin, D. Yang, G. Lin*. Effect of Structural Modification on the Gastrointestinal Stability and Hepatic Metabolism of a-Aminoxy Peptides. Amino Acids, 2012, 43, 2073–2085.

116.        B. Shen, X. Li, F. Wang, X.-Q. Yao*, D. Yang*. A Synthetic Chloride Channel Restores Chloride Conductance in Human Cystic Fibrosis Epithelial Cells. PLoS ONE, 2012, 7(4), e34694.

115.        N. Ieda, H. Nakagawa*, T. Peng, D. Yang, T. Suzuki, N. Miyata*. Photo-controllable Peroxynitrite Generator Based on N-Methyl-N-nitrosoaminophenol for Cellular Application. J. Am. Chem. Soc. 2012, 134, 2563–2568.

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114.        F. Chen, B. Ma, Z.-C. Yang, G. Lin*, D. Yang*. Extraordinary Metabolic Stability of Peptides Containing a-Aminoxy Acids. Amino Acids 2012, 43, 499–503.

113.        B. Ma, S. Chai, N. Li, K. K.W. To, W. L. T. Kan, D. Yang, G. Lin*. Reversal of P-Glycoprotein-Mediated Multidrug Resistance by a Synthetic a-Aminoxy Peptidomimetic. Int. J. Pharm. 2011, 424, 33–39.

112.        A. C. H. Ma, T. K. Fung, R. H. C. Lin, M. I. S. Chung, D. Yang, A. Y. H. Leung*. Methionine Aminopeptidase 2 Is Required for Hematopoietic Stem Cell Initiation and Proliferation. Blood, 2011, 118, 5448–5457.

Figure 2. Knockdown of metap2 affected embryonic hematoporesis. (A) WISH comparing expression of mpo at 18 hpf between control and metap2MO (control, 90.6% 0.8% with normal mpo expression in total 85 embryos; metap2MO, 72.1% 2.6% with increased mpo expression in total 68 embryos; n 3). (B-C) WISH comparing expression of c-myb between control and metap2MO at 36 hpf (B; control, 93.8% 1.3% in total 128 embryos with normal c-myb expression; metap2MO, 82.6% 2.7% in total 121 embryos with reduced c-myb expression; n 5) and 48 hpf (C; control, 89.2% 1.0% in total 148 embryos with normal c-myb expression; metap2MO, 78.9% 3.0% in total 147 embryos with reduced c-myb expression; n 5). (D) WISH showing the expression of c-myb at 36 (rescued c-myb expression, 75.3% 3.8% in total 72 embryos, n 3) and 48 hpf (rescued c-myb expression, 77.0% 4.0% in total 87 embryos, n 3) in metap2MO rescued by metap2 mRNA. Bars represent 250 m.

111.        F. Gaupels, E. Spiazzi-Vandelle, D. Yang, M. Delledonne*. Detection of Peroxynitrite Accumulation in Arabidopsis thaliana During the Hypersensitive Defense Response. Nitric Oxide 2011, 25, 222–228.

110.        D. Xing, D. Yang*. Highly Efficient Gold(I)-Catalyzed Overman Rearrangement in Water. Beilstein J. Org. Chem. 2011, 7, 781–785.

109.        B. Ma, H.-Y. Zha, N. Li, D. Yang, G. Lin*. Effect of Structural Modification of α-Aminoxy Peptides on Their Intestinal Absorption and Transport Mechanism. Mol. Pharmaceutics 2011, 8, 1073–1082.

108.        K.-T. Yip, D. Yang*. Pd(II)-Catalyzed Oxidative Cascade Cyclization Reactions: Scope and Mechanistic Investigations. Chem. Asian J. 2011, 6, 2166–2175.

107.        Z.-G. Jiao, X.-W. Chang, W. Ding, G.-J. Liu, K.-S. Song, N.-Y. Zhu, D.-W. Zhang*, D. Yang*. N–O Turn and Helix Induced by b2-Aminoxy Peptides: Synthesis and Conformational Studies. Chem. Asian J. 2011, 6, 1791–1799.

106.        N. Ieda, H. Nakagawa*, T. Horinouchi, T. Peng, D. Yang, H. Tsumoto, T. Suzuki, K. Fukuhara, N. Miyata*.  Peroxynitrite Generation from NO-releasing Nitrobenzene Derivative in Response to Photoirradiation. Chem. Comm. 2011, 47, 6449–6451.

105.        K.-T. Yip, D. Yang*. Pd(II)-Catalyzed Intramolecular Amidoarylation of Alkenes with Molecular Oxygen as Sole Oxidant. Org. Lett., 2011, 13, 2134–2137.

104.        F. Chen, C.-J. Shen, D. Yang*. A Simple Protocol for the Synthesis of 2-Arylbenzoxazoles by Oxidation with o-Iodoxybenzoic Acid (IBX) and Its Application in the Synthesis of Arylbenzoxazole-containing Amino Acids. Tetrahedron Lett. 2011, 52, 2128–2131. (Invited article for a special issue dedicated  to Professor Harry Wasserman)

103.        T. Peng, D. Yang*. HKGreen-3: A Rhodol-Based Fluorescent Probe for Peroxynitrite. Org. Lett., 2010, 12, 4932–4935.

102.        D. Yang*, X.-W. Chang, D.-W. Zhang*, Z.-F. Jiang, K.-S. Song, Y.-H Zhang, N.-Y. Zhu, L.-H. Weng, M.-Q. Chen. Chiral a-Aminoxy Acid/Achiral Cyclopropane a-Aminoxy Acid Unit as a Building Block for Constructing a N-O Helix. J. Org. Chem. 2010, 75, 4796–4805.

101.        J.-D. Yu, W. Ding, G.-Y. Lian, K.-S. Song, D.-W. Zhang, X. Gao, D. Yang*. Selective Approach toward Multi-functionalized Lactams by Lewis Acid-promoted PhSe Group Transfer Radical Cyclization. J. Org. Chem. 2010, 75, 3232–3239.

100.        R. Y. Kao*, D. Yang, L.-S. Lau, W. H. W. Tsui, L.-H. Hu, J. Dai, M.-P. Chan, C.-M. Chan, P. Wang, B.-J. Zheng, J. Sun, J.-D. Huang, J. Madar, G.-H. Chen, H.-L. Chen, Y. Guan, K.-Y. Yuen*. Identification of Influenza A Nucleoprotein as an Antiviral Target. Nature Biotechnology, 2010, 28, 600-605.

99.           D. Xing, D. Yang*. Gold(I)-Catalyzed Highly Regio- and Stereoselective Decarboxylative Amination of Allylic N-Tosylcarbamates via Base-Induced Aza-Claisen Rearrangement in Water. Org. Lett. 2010, 12, 1068–1071.

98.    D. Yang*, G.-J. Liu, Y. Hao, W. Li, Z.-M. Dong, D.-W. Zhang, N.-Y. Zhu. Conformational Studies on Peptides of α-Aminoxy Acids that Have Functionalized Side Chains. Chem. Asian J. 2010, 5, 1356–1363.

97.           P. Tao, D. Yang*. Construction of a Library of Rhodol Fluorophores for Developing New Fluorescent Probes. Org. Lett. 2010, 12, 496–499.

96.    Y.-H. Zhang, K.-S. Song, N.-Y. Zhu, D.Yang*. Effect of Backbone Stereochemistry on the Folding of Acyclic b2,3-Aminoxy Peptides. Chem. Eur. J. 2010, 16, 577-587.

95.    W. He, K.-T. Yip, N.-Y. Zhu, D. Yang*. Pd(II)/tBu quinolineoxazoline: An Air-stable and Modular Chiral Catalyst System for Enantioselective Oxidative Cascade Cyclization. Org. Lett. 2009, 11, 5626-5628.

94.    D. Yang*, G.-Y. Lian, H.-F. Yang, J.-D. Yu, D.-W. Zhang*, X. Gao. Synthesis of g-Butyrolactams by Photoinduced PhSe-Group-Transfer Radical Cyclization and Formal Synthesis of (±)-Isocynometrine Using Diphenyldiselenide as Promoter. J. Org. Chem. 2009, 74, 8610–8615.

93.    X.-W. Chang, D.-W. Zhang*, F. Chen, Z.-M. Dong, D. Yang*. A Concise Asymmetric Route to Chiral a-Aminoxy Acids. Synlett, 2009, 3159–3162.

92.    X. Li, B. Shen, X.-Q. Yao*, D. Yang*. A synthetic chloride channel regulates cell membrane potentials and voltage-gated calcium channels. J. Am. Chem. Soc. 2009, 131, 13676–13680.

91.    O.-Y. Lee, K.-L. Law, D. Yang*. Secondary Amine Formation from Reductive Amination of Carbonyl Compounds Promoted by Lewis Acid Using the InCl3/Et3SiH System. Org. Lett. 2009, 11, 3302–3305.

90.           Z.-N. Sun, H.-L. Wang, F.-Q. Liu, Y. Chen, P. K. H. Tam, D. Yang*, BODIPY-based Fluorescent Probe for Peroxynitrite Detection and Imaging in Living Cells. Org. Lett. 2009, 11, 1887–1890.

89.           K.-T. Yip, N.-Y. Zhu, D. Yang*. Palladium-Catalyzed Highly Diastereoselective Oxidative Cascade Cyclization Reactions. Org. Lett. 2009, 11, 1911–1914. 

88.           O.-Y. Lee, K.-L. Law, C.-Y. Ho, D. Yang*. Highly Chemoselective Reductive Amination of Carbonyl Compounds Promoted by InCl3/Et3SiH/MeOH System J. Org. Chem. 2008, 73, 8829-8837.

87.           X. Li, Y.-D. Wu*, D. Yang*. a-Aminoxy Acids: New Possibilities from Foldamers to Anion Receptors and Channels. Acc. Chem. Res. 2008, 41, 1428-1438.

86.           D. Yang*, G.-J. Liu, Z.-G. Jiao, D.-W. Zhang*, Z. Luo, K.-S. Song, M.-Q. Chen. Disulfide Bond Creates a Small Connecting Loop in Aminoxy Peptide Backbone. Chem. Eur. J. 2008, 14, 10297-10302.

85.           Z.-N. Sun, F.-Q. Liu, Y. Chen, P. K. H. Tam, D. Yang*. A Highly Specific BODIPY-Based Fluorescent Probe for the Detection of Hypochlorous Acid. Org. Lett. 2008, 10, 2171-2174.

84.           K. F. Wong, J. K. Chan, K. L. Chan, P. Tam, D. Yang, S. T. Fan, J. M. Luk*. Immunochemical characterization of the functional constituents of Tripterygium wilfordii contributing to its anti-inflammatory property. Clin. Exp. Pharmacol. Physiol. 2008, 35, 55-59.

83.           F. Chen, K.-S. Song, Y.-D. Wu, D. Yang*. Synthesis and Conformational Studies of g–Aminoxy Peptides. J. Am. Chem. Soc. 2008, 130, 743-755.

82.           J.-H. Pan, M. Yang, Q. Gao, N.-Y. Zhu, D. Yang*. Bulky Thioureas as New Ligands for Gold(I)-Catalyzed Cyclization of Acetylenic 1,3-Dicarbonyl Compounds. Synthesis 2007, 2539-2544. (Invited article for Special Topic on thioureas)

81.           X. Li, B. Shen, X.-Q. Yao, D. Yang*. A Small Synthetic Molecule Forms Chloride Channels to Mediate Chloride Transport across Cell Membranes. J. Am. Chem. Soc. 2007, 129, 7264-7265.

80.           F. Chen, D. Yang*. Condensation of Amino Acids to Form Peptides in Aqueous Solution Induced by the Oxidation of Sulfur(IV): An Oxidative Model for Prebiotic Peptide Formation. Origins Life Evol. Biospheres, 2007, 37, 47-54.

79.           D. Yang*, Y.-L. Yan, B.-F. Zheng, Q. Gao, N.-Y. Zhu. Copper(I)-Catalyzed Chlorine Atom Transfer Radical Cyclization Reactions of Unsaturated a-Chloro b-Keto Esters. Org. Lett. 2006, 8, 5757-5760.

78.           M. Yang, K.-T. Yip, J.-H. Pan, Y.-C. Chen, N.-Y. Zhu, D. Yang*. A Sterically Bulky Cyclic Thiourea as an Efficient Ligand for Palladium-Catalyzed Aerobic Oxidation of Alcohols. Synlett 2006, 3057-3060. (Invited article for a special issue dedicated  to Professor Richard Heck)

77.           X. Li, D. Yang*. Peptides of Aminoxy Acids as Foldamers. Chem. Commun. 2006, 3367 -3379. (Invited Feature Article)

76.           D. Yang*, H.-L. Wang, Z.-N. Sun, N.-W. Chung, J.-G. Shen. A Highly Selective Fluorescent Probe for the Detection and Imaging of Peroxynitrite in Living Cells. J. Am. Chem. Soc. 2006, 128, 6004-6005.

75.           K.-T. Yip, M. Yang, K.-L. Law, N.-Y. Zhu, D. Yang*. Pd(II)-Catalyzed Enantioselective Oxidative Tandem Cyclization Reactions. Synthesis of Indolines through C-N and C-C Bond Formation. J. Am. Chem. Soc. 2006, 128, 3130-3131.

74.           X.-G. Guan, D. L. Phillips*, D. Yang*. A Density Functional Theory Study of the 5-Exo Cyclization Reactions of a-Substituted 6,6-Diphenyl-5-hexenyl Radicals. J. Org. Chem. 2006, 71, 1984-1988.

73.    W. Chen , R. Li, B. Han, B.-J. Li , Y.-C. Chen *, Y. Wu, L.-S. Ding , D. Yang. The Design and Synthesis of Bis(thiourea) Ligands and Their Application in Pd-Catalyzed Heck and Suzuki Reactions Under Aerobic Conditions. Eur. J. Org. Chem. 2006, 1177-1184.

72.    D. Yang*, B.-F. Zheng, Q. Gao, S. Gu, N.-Y. Zhu. Enantioselective PhSe Group Transfer Tandem Radical Cyclization Reactions Catalyzed by a Chiral Lewis Acid. Angew. Chem., Int. Ed.  2006, 45, 255-258.  

71.           D. S. S. Kumar, C. S. Lau*, J. M. F. Wan, D. Yang, K. D. Hyde. Immunomodulatory compounds from Pestalotiopsis leucothes, an endophytic fungus from Tripterygium wilfordii.  Life Sciences 2005, 78, 147-156.

70.           K.-T. Yip, J.-H. Li, O.-Y. Lee, D. Yang*. Aerobic Oxidative Cyclization Under Pd(II) Catalysis: A Regioselective Approach to Heterocycles. Org. Lett. 2005, 7, 5717-5719.

69.           Li, J.-H.*; Zhu, Q.-M.; Liang, Y.; Yang, D. Efficient and Reusable PdCl2(MeCN)2/CuCl2/PEG-400 System for Cyclization of Alkenyl b-Keto Esters and Amides. J. Org. Chem. 2005, 70, 5347-5349.

68.           D. Yang*, X. Li, Y.-F. Fan, D.-W. Zhang. An Enantioselective Carboxylate Receptor Derived from a-Aminoxy Acids Functions as a Chiral Shift Reagent. J. Am. Chem. Soc. 2005, 127, 7996-7997.

67.           Q. Gao, B.-F. Zheng, J.-H. Li, D. Yang*. Ni(II)-Catalyzed Conia-Ene Reaction of 1,3-Dicarbonyl Compounds with Alkynes. Org. Lett. 2005, 7, 2185-2188.

66.           D. Yang*, X. Li, Y. Sha, Y.-D. Wu*. A Cyclic Hexapeptide Comprising Alternating a-Aminoxy Acids and a-Amino Acids is a Selective Chloride Anion Receptor. Chem. Eur. J.  2005, 11, 3005-3009.

65.           C.-Y. Ho, Y.-C. Chen, M.-K. Wong, D. Yang*. Epoxidation of Olefins Catalyzed by Chiral Fluorinated Secondary Amines. J. Org. Chem. 2005, 70, 898-906.

64.           F. Chen, N.-Y. Zhu, D. Yang*. g4-Aminoxy Peptides as New Peptidomimetic Foldamers. J. Am. Chem. Soc. 2004, 126, 15980-15981.

63.           D. Yang,* Q. Gao, B.-F. Zheng, N.-Y. Zhu. Et2AlCl-Promoted Asymmetric Phenylseleno Group Transfer Radical Cyclization Reactions of Unsaturated b-Hydroxy Esters. J. Org. Chem. 2004, 69, 8821-8828.

62.           D. Yang*, D.-W. Zhang, Y. Hao, Y.-D. Wu, S.-W. Luo, N.-Y. Zhu. b2, 3-Cyclic Aminoxy Acids: Rigid and Ring Size-Independent Building Blocks of Foldamers. Angew. Chem., Int. Ed.  2004, 43, 6719-6722.

61.           R.Y. Kao*, W.H.W. Tsui, T.S.W. Lee, J.A. Tanner, R.M. Watt, J.D. Huang, L.H. Hu, G.H. Chen, Z.W. Chen, L.Q. Zhang, T. He, K.H. Chan, H. Tse, A.P.C. To, L.W.Y. Ng, B.C.W. Wong, H.W. Tsoi, D. Yang, D.D. Ho, K.Y. Yuen. Identification of Novel Small Molecule Inhibitors of Severe Acute Respiratory Syndrome Associated Coronavirus by Chemical Genetics. Chem. Biol. 2004, 11, 1293-1299.

60.           D. Yang*, Y.-H. Zhang, B. Li, D.-W. Zhang. The Synthesis of Chiral b3-Aminoxy Peptides. J. Org. Chem. 2004, 69, 7577-7581.

59.           D. Yang. Ketone-Catalyzed Asymmetric Epoxidation Reactions. Acc. Chem. Res. 2004, 37, 497-505. (Invited article to a special issue entitled “Enantioselective Organocatalysis”)

58.           D. Yang*, Y.-H. Zhang, B. Li, D.-W. Zhang, J. C.-Y. Chan, N.-Y. Zhu, S.-W. Luo, Y.-D. Wu*. Effect of Side Chains on Turns and Helices in Peptides of b3-Aminoxy Acids. J. Am. Chem. Soc. 2004, 126, 6956-6966.

57.           D. Yang*, Y.-C. Chen, N.-Y. Zhu. Sterically Bulky Thioureas as Air and Moisture Stable Ligands for Pd-Catalyzed Heck Reactions of Aryl Halides. Org. Lett. 2004, 6, 1577-1580.

56.           D. Yang*, F. Chen, Z.-M. Dong, D.-W. Zhang. Ruthenium-Catalyzed Oxidative Cleavage of Alkynes to Carboxylic Acids.  J. Org. Chem. 2004, 69, 2221-2223.

55.           D. Yang*, J. Qu, D.-P. Wang, Y. Ren, Y.-D. Wu*. A Reverse Turn Structure Induced by Two Consecutive D,L-a-Aminoxy Acids. J. Am. Chem. Soc. 2003, 125, 14452-14457.

54.           D. Yang*, M. Yang, N.-Y. Zhu. Chiral Lewis Acid-Catalyzed Enantioselective Intramolecular Carbonyl Ene Reactions of Unsaturated α-Keto Esters. Org. Lett. 2003, 5, 3749-3752.

53.           D. Yang*, B.-F. Zheng, S. Gu, P. W. H. Chan, N.-Y. Zhu. Lewis Acid-Catalyzed Asymmetric Atom Transfer Radical Cyclization Reactions of a-Bromo Oxazolidinones. Tetrahedron: Asymmetry 2003, 14, 2927-2937.  (Invited article to a special edition entitled “Stereoselective Radical Reactions”)

52.           D. Yang*, Y.-L. Yan, K.-L. Law, N.-Y. Zhu. Lewis Acid-Catalyzed Atom Transfer Radical Cyclization of Unsaturated b-Keto Amides. Tetrahedron 2003, 59, 10465-10475. (Invited article to a special edition entitled “Recent Advances in Rare Earth Chemistry”)

51.           D. Yang*, W. Li, J. Qu, S.-W. Luo, Y.-D. Wu*. A New Strategy to Induce g-Turns: Peptides Composed of Alternating a-Aminoxy Acids and a-Amino Acids. J. Am. Chem. Soc. 2003, 125, 13018-13019.

50.           D. Yang*, J.-H. Li, Q. Gao, Y.-L. Yan. Lanthanide Triflate-Promoted Palladium-Catalyzed Cyclization of Alkenyl b–Keto Esters and Amides. Org. Lett. 2003, 5, 2869-2871.

49.           M.-K. Wong, N.-W. Chung, L. He, X.-C. Wang, Z. Yan, Y.-C. Tang, D. Yang*. Investigation on the Regioselectivities of Intramolecular Oxidation of Unactivated C-H Bonds by Dioxiranes Generated in Situ.  J. Org. Chem. 2003, 68, 6321-6328.

48.           M.-K. Wong, N.-W. Chung, L. He, D. Yang*. Substituent Effects on Regioselective Intramolecular Oxidation of Unactivated C-H Bonds: Stereoselective Synthesis of Substituted Tetrahydropyrans. J. Am. Chem. Soc. 2003, 125, 158-162.

47.             D. Yang*, Y.-L. Yan, B. Lui. Mild a-Halogenation Reactions of 1,3-Dicarbonyl Compounds Catalyzed by Lewis Acids. J. Org. Chem. 2002, 67, 7429-7431.

46.           D. Yang*, J. Qu, W. Li, Y.-H. Zhang, D.-P. Wang, Y.-D. Wu*. A Cyclic Hexapeptide of D,L-a-Aminoxy Acids as a Selective Receptor for Chloride Ion. J. Am. Chem. Soc. 2002, 124, 12410-12411.

45.           D. Yang*, Q. Gao, C.-S. Lee, K.-K. Cheung. A Novel Intramolecular Cyclopropanation Reaction of Unsaturated b-Keto Esters. Org. Lett. 2002, 4, 3271-3274.

44.           D. Yang*, Y.-H. Zhang, N. Y. Zhu. β2,2-Aminoxy Acids: A New Building Block for Turns and Helices. J. Am. Chem. Soc. 2002, 124, 9966-9967.

43.           D. Yang*, S. Gu, H.-W. Zhao, Y.-L. Yan, N.-Y. Zhu. Atom-Transfer Tandem Radical Cyclization Reactions Promoted by Lewis Acids. Angew. Chem., Int. Ed. 2002, 41, 3014-3017.

42.           D. Yang*, Q. Gao, O.-Y. Lee. Lewis Acid-Promoted Phenylseleno Group Transfer Tandem Radical Cyclization Reactions. Org. Lett. 2002, 4, 1239-1241.

41.           D. Yang*, B. Li, F.-F. Ng, Y.-L. Yan, J. Qu, Y.-D. Wu. Synthesis and Characterization of Chiral N-O Turns Induced by a-Aminoxy Acids. J. Org. Chem. 2001, 66, 7303-7312.

40.           X.-H. Jiang, B. C.-Y. Wong*, M. C.-M. Lin, G.-H. Zhu, H.-F. Kung, S.-H. Jiang, D. Yang, S.-K. Lam.  Functional p53 is required for Triptolide-induced apoptosis and AP-1 and Nuclear Factor-kB activation in gastric cancer cells. Oncogene, 2001, 20, 8009-8018.

39.           D. Yang*, S. Gu, Y.-L. Yan, N.-Y. Zhu, K.-K. Cheung. Highly Enantioselective Atom-transfer Radical Cyclization Reactions Catalyzed by Lewis Acids. J. Am. Chem. Soc. 2001, 123, 8612-8613.

38.           M.-K. Wong*, L.-M. Ho, Y.-S. Zheng, C.-Y. Ho, D. Yang*. Asymmetric Epoxidation of Olefins Catalyzed by Chiral Iminium Salts Generated in situ from Amines and Aldehydes. Org. Lett. 2001, 3, 2587-2590.

37.           D. Yang*, C. Zhang. Ruthenium-Catalyzed Oxidative Cleavage of Olefins to Aldehydes. J. Org. Chem. 2001, 66, 4814-4818.

36.           D. Yang*, M. Xu. First Enantioselective Syntheses of (+) and (-)-Wilforonide by Using Chiral Auxiliaries Derived from the Same Chiral Source. Org. Lett. 2001, 3, 1785-1788.

35.           D. Yang*, G.-S. Jiao, Y.-C. Yip, T.-H. Lai, M.-K. Wong. Kinetic Resolution of Acyclic Secondary Allylic Silyl Ethers Catalyzed by Chiral Ketones. J. Org. Chem. 2001, 66, 4619-4624.

34.           M.-K. Wong*, C.-W. Yu, W.-H. Yuen, D. Yang*. Synthesis of a-Keto Esters and Amides via Oxidative Cleavage of Cyanoketophosphoranes by Dimethyldioxirane. J. Org. Chem. 2001, 66, 3606-3609.

33.           D. Yang*, Y.-C. Yip, G.-S. Jiao, M.-K. Wong.  In Situ Catalytic Epoxidation of Olefins with Tetrahydrothiopyran-4-one and Oxone: 2-Methyl-2,3-Diphenyloxirane. Org. Syn. 2001, 78, 225-233.

32.           D. Yang*, M. Xu, M.-Y. Bian. Chiral Auxiliaries for Asymmetric Radical Cyclization Reactions: Application to the Enantioselective Synthesis of (+)-Triptocallol. Org. Lett. 2001, 3, 111-114.

31.           D. Yang*, G.-S. Jiao. Highly b-Selective Epoxidation of D5-Unsaturated Steroids Catalysed by Ketones. Chem. Eur. J. 2000, 6, 3517-3521.

30.           D. Yang*, M.-K. Wong, Z. Yan.  Regioselective Intramolecular Oxidation of Phenols and Anisols by Dioxiranes Generated in situ. J. Org. Chem. 2000, 65, 4179-4184.

29.           D. Yang*, C. Zhang, X.-C. Wang. A Novel Epoxidation Reaction of Olefins Using a Combination of Chloramine-M, Benzaldehyde, and Benzyltriethylammonium Chloride. J. Am. Chem. Soc. 2000, 122, 4039-4043.

28.           D. Yang*, X.-Y. Ye, M. Xu. Enantioselective Total Synthesis of (-)-Triptolide, (-)-Triptonide, and (+)-Triptophenolide, and (+)-Triptoquinonide. J. Org. Chem. 2000, 65, 2208-2217.

27.           D. Yang*, X.-Y. Ye, M. Xu, K.-W. Pang, K.-K. Cheung. Investigation of Mn(III)-Based Oxidative Free Radical Cyclization Reactions toward the Synthesis of Triptolide: The Effects of Lanthanide Triflates and Substituents on Stereoselectivity. J. Am. Chem. Soc. 2000, 122, 1658-1663.

26.           D. Yang*, Y.-C. Tang, J. Chen, X.-C. Wang, M. D. Bartberger, K. N. Houk*, L. Olson. Ketone-Catalyzed Decomposition of Peroxynitrite via Dioxirane Intermediates. J. Am. Chem. Soc. 1999, 121, 11976-11983.

25.           Y.-D. Wu*, D.-P. Wang, K. W. K. Chan, D. Yang*. Theoretical Study of Peptides Formed by Aminoxy Acids.  J. Am. Chem. Soc. 1999, 121, 11189-11196.

24. K. K. Tong, D. Yang, E. Y. T. Chan, P. K. Y. Chiu, K. S. Yau, C. S. Lau*.  Down Regulation of Lymphocyte Activity and Human Synovial Fibroblast Growth in Rheumatoid Arthritis by Triptolide.  Drug Dev. Res. 1999, 47, 144-53.

23. D. Yang*, X.-Y. Ye, S. Gu, M. Xu. Lanthanide Triflates Catalyze Mn(III)-Based Oxidative Radical Cyclization Reactions. Enantioselective Synthesis of (–)-Triptolide, (–)-Triptonide, and (+)-Triptophenolide. J. Am. Chem. Soc. 1999, 121, 5579–5580.

22.  D. Yang*, G.-S. Jiao, Y.-C. Yip, M.-K. Wong. Diastereoselective Epoxidation of Cyclohexene Derivatives by Dioxiranes Generated in situ. Importance of Steric and Field Effects. J. Org. Chem. 1999, 64, 1635–1639.

21.    D. Yang*, J. Qu, B. Li, F.-F. Ng, X.-C. Wang, K.-K. Cheung, D.-P. Wang, Y.-D. Wu*. Novel Turns and Helices in Peptides of Chiral a-Aminoxy Acids. J. Am. Chem. Soc. 1999, 121, 589–590.

20.    D. Yang*, Y.-C. Yip, M.-W. Tang, M.-K. Wong, K.-K. Cheung.  Novel Cyclic Ketones for Catalytic Oxidation Reactions.  J. Org. Chem. 1998, 63, 9888–9894.

19.    D. Yang*, Y.-C. Yip, G.-S. Jiao, M.-K. Wong.  Design of Efficient Ketone Catalysts for Epoxidation by Using the Field Effect.  J. Org. Chem. 1998, 63, 8952–8956.

18. D. Yang*, X.-Y. Ye, M. Xu, K.-W. Pang, N. Zou, R. M. Letcher.  A Concise Total Synthesis of Triptolide.  J. Org. Chem. 1998, 63, 6446–6447.

17. D. Yang*, Y.-C. Yip, J. Chen, K.-K. Cheung.  Significant Effects of Non-Conjugated Remote Substituents in Catalytic Asymmetric Epoxidation.  J. Am. Chem. Soc. 1998, 120, 7659–7660.

16. D. Yang*, M.-K. Wong, X.-C. Wang, Y.-C. Tang.  Regioselective Intramolecular Oxidation of Unactivated C–H Bonds by Dioxiranes Generated in situJ. Am. Chem. Soc. 1998, 120, 6611–6612.

15. D. Yang*, M.-K. Wong, Y.-C. Yip, X.-C. Wang, M.-W. Tang, J.-H. Zheng, K.-K. Cheung.  Design and Synthesis of Chiral Ketones for Catalytic Asymmetric Epoxidation of Unfunctionalized Olefins.  J. Am. Chem. Soc. 1998, 120, 5943–5952.

14. D. Yang*, Y.-C. Yip, X.-C. Wang.  Oxidative Cleavage of Aryl Oxazolines Using Methyl(trifluoromethyl)dioxirane Generated in situ.  Tetrahedron Lett. 1997, 38, 7083–7086.

13. D. Yang*, M.-K. Wong, K.-K. Cheung, E. W. C. Chan, Y. Xie.  Studies on Triepoxide Analogs of Triptolide.  Tetrahedron Lett. 1997, 38, 6865–6868.

12. D. Yang*, X.-C. Wang, M.-K. Wong, Y.-C. Yip, M.-W. Tang.  Highly Enantioselective Epoxidation of Trans-Stilbenes Catalyzed by Chiral Ketones.  J. Am. Chem. Soc. 1996, 118, 11311–11312.

11. D. Yang*, F.-F. Ng, Z.-J. Li, Y.-D. Wu*, K. W.-K. Chan, D.-P. Wang.  An Unusual Turn Structure in Peptides Containing a-Aminoxy Acids.  J. Am. Chem. Soc. 1996, 118, 9794–9795.

10. D. Yang*, Y.-C. Yip, M.-W. Tang, M.-K. Wong, J.-H. Zheng, K.-K. Cheung.  A C2 Symmetric Chiral Ketone for Catalytic Asymmetric Epoxidation of Unfunctionalized Olefins.  J. Am. Chem. Soc. 1996, 118, 491–492.

9.  D. Yang*, M.-K. Wong, Y.-C. Yip. Epoxidation of Olefins Using Methyl(trifluoromethyl)dioxirane Generated in situJ. Org. Chem. 1995, 60, 3887–3889.

8.  S.-H. Kim, D. Augeri, D. Yang, D. Kahne*.  Concise Synthesis of the Calicheamicin Oligosaccharide Using the Sulfoxide Glycosylation Method.  J. Am. Chem. Soc. 1994, 116, 1766–1775.

7.  M. K. Rosen, D. Yang, P. K. Martin, S. L. Schreiber*.  Activation of an Inactive Immunophilin by Mutagenesis.  J. Am. Chem. Soc. 1993, 115, 821–822.

6.  D. Yang, M. K. Rosen, S. L. Schreiber*.  The Composite FKBP-FK506 Surface That Contacts Calcineurin.  J. Am. Chem. Soc. 1993, 115, 819–820.

5.  S. Walker, D. Yang, D. Kahne*, D. Gange.  Conformational Analysis of the N–O Bond in the Calicheamicin Oligosaccharides.  J. Am. Chem. Soc. 1991, 113, 4716–4717.

4.  D. Yang, S. H. Kim, D. Kahne*.  Construction of Glycosidic N–O Linkages in Oligosaccharides. J. Am. Chem. Soc. 1991, 113, 4715–4716.

3.       R. Breslow*, J. W. Canary, M. Varney, S. T. Waddell, D. Yang.  Artificial Transaminases Linking Pyridoxamine to Binding Cavities: Controlling the Geometry.  J. Am. Chem. Soc. 1990, 112, 5212–5219.

2.       D. Kahne*, D. Yang, M. D. Lee.  Preparation of the 4-Ethylamino Sugar of Calicheamicin: Assignment of Absolute Configuration.  Tetrahedron Lett. 1990, 31, 21–22.

1.  D. Kahne*, D. Yang, J. J. Lim, R. Miller, E. Paguaga.  The Use of Alkoxy Substituted Anomeric Radicals for the Construction of b-Glycosides.  J. Am. Chem. Soc. 1988, 110, 8716–8717.