Fushman, David - University of Maryland - Department of Chemistry & Biochemistry

个人简介

M.S. in Physics, University of Kazan, Russia, graduated summa cum laude 1978 Ph.D. in Physics and Math.Sci., University of Kazan, Russia 1985 1985-1991Scientist, Mol. Biophys. Lab, Kazan Inst. of Biology, USSR Acad. Sci., Russia 1991-1993 Alexander von Humboldt Fellow, Institute of Biophysical Chemistry, University of Frankfurt, Germany 1993 Research Associate, Inst. of Biophysical Chemistry, University of Frankfurt,Germany 1994–2000 Research Associate, Physical Biochemistry Lab, The Rockefeller University, New York

研究领域

Structure, dynamics, stability, and function of biological macromolecules. Structural biology and molecular mechanisms of intracellular signaling. Ubiquitin-proteasome system. Structure and dynamics of multidomain proteins. Development and application of new robust theoretical and experimental approaches to protein structure and dynamics in order to understand their roles in protein stability and function.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

K. Berlin, N. A. Gumerov, D. Fushman, R. Duraiswami, "Hierarchical O(N) Computation of Small-Angle Scattering Profiles and their Associated Derivatives", J Appl Cryst (2014), in press. S. Y. Lee, L. Pullen, D. J. Virgil, C. A. Castañeda, D. Abeykoon, D. N. A. Bolon, D. Fushman, "Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function", J Mol Biol (2014) 426, 1377-1389. K. Berlin, A. Longhini, T. K. Dayie, D. Fushman, "Deriving Quantitative Dynamics Information for Proteins and RNAs using ROTDIF with a Graphical User Interface", J Biomol NMR (2013) 57, 333-352. K. Berlin, C. A. Castañeda, D. Schneidman-Duhovny, A. Sali, A. Nava-Tudela, and D. Fushman, "Recovering a Representative Conformational Ensemble from Underdetermined Macromolecular Structural Data", J. Am. Chem. Soc. (2013) 135, 16595–16609. N. Haj-Yahya, M. Haj-Yahya, C. A. Castañeda, L. Spasser, H. P. Hemantha, M. Jbara, M. Penner, A. Ciechanover, D. Fushman, A. Brik, "Organic Chemistry Applied to Synthetic Proteins: Modifying the Vicinity of the Isopeptide Bond Revealed Differential Behavior of Ubiquitin Chains with Ubiquitin Interacting Proteins", Angew Chem Int Ed Engl (2013) 52, 11149-11153. C. A. Castañeda, T. R. Kashyap, M. A. Nakasone, S. Krueger, D. Fushman, "Unique structural, dynamical, and functional properties of K11-linked polyubiquitin chains", Structure (2013) 21, 1168-1181. E. K. Dixon, C. A. Castañeda, T. Kashyap, Y. Wang, D. Fushman, "Nonenzymatic assembly of branched polyubiquitin chains for structural and biochemical studies", Bioorganic & Medicinal Chemistry (2013) 21, 3421-3429. M. A. Nakasone, N. Livnat-Levanon, M. H. Glickman, R. E. Cohen, D. Fushman, "Mixed-linkage ubiquitin chains send mixed messages", Structure (2013) 21, 727-740. B. P. Roscoe, K. M. Thayer, K. B. Zeldovich, D. Fushman, D. N. A. Bolon, "Analyses of the effects of all ubiquitin point mutants on yeast growth rate", J. Mol. Biol. (2013) 425, 1363-1377. K. Wilkinson, D. Fushman, On the Chain Gang, The Scientist, July 2012 issue, pp. 40-45, http://the-scientist.com/2012/07/01/on-the-chain-gang/ R. K. Singh, S. Zerath, O. Kleifeld, M. Scheffner, M. H Glickman, D. Fushman, "Recognition and Cleavage of Rub1 and Rub1-Ubiquitin Chains by Components of the Ubiquitin-Proteasome System", Mol Cell Proteomics (2012) 11, 1595-611. J. Cannon, M. Nakasone, D. Fushman, C. Fenselau, "Proteomic Identification and Analysis of K63-linked Ubiquitin Conjugates", Anal Chem (2012) 84, 10121-8. M. D’Onofrio, E. Gianolio, A. Ceccon, F. Arena, S. Zanzoni, D. Fushman, S. Aime, H. Molinari, M. Assfalg, "High relaxivity supramolecular adducts between human liver fatty acid binding protein and amphiphilic Gd(III)-complexes: structural basis for the design of intracellular targeting MRI probes", Chemistry – A European Journal (2012) 18, 9919-9928. N. A. Gumerov, K. Berlin, D. Fushman, R. Duraiswami, "A Hierarchical Algorithm for Fast Debye Summation with Applications to Small Angle Scattering", J. Comput. Chem. (2012) 33, 1981-1996. M.-Y. Lai, D. Zhang, N. LaRonde-LeBlanc, D. Fushman (senior author), "Structural and biochemical studies of the open state of Lys48-linked diubiquitin", BBA – Molecular Cell Research (2012) 1823, 2046-2056. A. Lange, C. A. Castañeda, D. Hoeller, J.-M. Lancelin, D. Fushman, O. Walker, "Evidence for cooperative and domain-specific binding of the signal transducing adaptor molecule 2 (STAM2) to Lys63-linked diubiquitin", J. Biol. Chem. (2012) 287, 18687-99. R. Rosenzweig, V. Bronner, D. Zhang, D. Fushman, M. H. Glickman, "Rpn1 and Rpn2 coordinate ubiquitin processing factors at the proteasome", J. Biol. Chem. (2012) 287, 14659-71. D. Fushman, K. D. Wilkinson, "Structure and recognition of polyubiquitin chains of different lengths and linkage", F1000 Biol Rep 3 (2011) 26; DOI: 10.3410/B3-26. URL: http://f1000.com/reports/b/3/26. C. A. Castañeda, J. Liu, A. Chaturvedi, U. Nowicka, T. A. Cropp, D. Fushman, "Nonenzymatic Assembly of Natural Polyubiquitin Chains of Any Linkage Composition and Isotopic Labeling Scheme", J. Am. Chem. Soc. 133 (2011) 17855-17868. C. A. Castañeda, L. Spasser, S. N. Bavikar, A. Brik, D. Fushman, "Segmental Isotopic Labeling of Ubiquitin Chains to Unravel Monomer- Specific Molecular Behavior", Angew Chem Int Ed Engl 50 (2011) 11210-11214.