个人简介

1985年获得中国科技大学生物系学士学位；1988年获得中国科学院生物物理研究所硕士学位；1995年获美国麻省理工学院（MIT）生物系博士学位；1995-1998年在美国哈佛大学做博士后研究（IrvingtonFellow）. 1999.3-2004.6美国华盛顿大学助理教授（tenure-track）； 2004.7-2009.6美国华盛顿大学副教授（终身）； 2009.7-2019.8美国华盛顿大学正教授（终身）； 2019年8月底加入上海科技大学生命科学与技术学院，任终身正教授

研究领域

结构生物学与细胞信号传导

（1）Wnt信号通路的分子机制，从Wnt蛋白的合成分泌，细胞表面受体结合，穿膜信号传导，b-catenin在细胞质内的降解，到细胞核内的Wntenhanceosome的抑制和激活; （2）重要癌症治疗新靶点的分子机制与结构研究； （3）蛋白质修饰酶的结构功能关系研究； （4）蛋白质设计与蛋白质工程

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.MaD,WangZ,MerrikhCN,LangKS,LuP,LiX,MerrikhH,RaoZ,XuW.*(2018).Crystalstructureofamembrane-boundO-acyltransferase.Nature,562,286-290. 2.DaRosaP,WangZ,JiangX,PrunedaJN,CongF,KlevitR*,andXuW.*(2015).AllostericactivationoftheRNF146ubiquitinligasebyapoly(ADP-ribose)signal.Nature.517(7533):223-6. 3.ChoU,andXuW.*(2007).Crystalstructureofaproteinphosphatase2Aheterotrimericholoenzyme.Nature(Article),445,53-57. 4.GrahamT,WeaverC,MaoF,KimelmanD,andXuW.*(2000).CrystalStructureofabeta-catenin/Tcfcomplex.Cell,103,885-896. 5.LuP,MinD,DiMaioF,WeiKY,VaheyMD,BoykenSE,ChenZ,FallasJA,UedaG,ShefflerW,MulliganVK, XuW,BowieJU,BakerD*.(2018).Accuratecomputationaldesignofmultipasstransmembraneproteins.Science,359,1042-1046. 6.ShenG,KeJ,WangZ,ChengZ,GuX,WeiY,MelcherK,XuHE*,andXuW.*(2015).StructuralbasisoftheNorrin-Frizzled4interaction.CellResearch.25,1078-1081 7.SunW,ZhuYJ,WangZ,ZhongQ,GaoF,LouJ,GongW*,andXuW.*(2013).CrystalstructureoftheyeastTSC1coredomainandimplicationsfortuberoussclerosispathologicalmutations.NatureCommunications.2013;4:2135. 8.WangZ,MichaudGA,ChengZ,ZhangY,HindsTR,FanE,CongF,andXuW.*(2012).Recognitionoftheiso-ADP-ribosemoietyinpoly(ADP-ribose)byWWEdomainssuggestsageneralmechanismforpoly(ADP-ribosyl)ationdependentubiquitination.Genes&Development,26,235-240. 9.MorroneS,ChengZ,MoonRT,CongF,XuW.*(2012).CrystalstructureofaTankyrase-AxincomplexanditsimplicationsforAxinturnoverandTankyrasesubstraterecruitment.PNAS,109,1500-1505. 10.ChengZ,BiecheleT,WeiZ,MorroneS,MoonRT,WangL,andXuW.*(2011).CrystalstructuresoftheextracellulardomainofLRP6anditscomplexwithDKK1.NatureStructural&MolecularBiology,18,1204-1210. 11.XuZ,CetinB,AngerM,ChoU,HelmhartW,NasmythK*,andXuW.*(2009).StructureandfunctionofthePP2A-shugoshininteraction.MolecularCell,35,426-441. 12.LiuJ,PhilipsB,AmayaM,KimbleJ*,andXuW.*(2008).TheC.elegansSys-1proteinisabonafidebeta-catenin.DevelopmentalCell,14,751-761. 13.ChoU,MorroneS,SablinaAA,ArroyoJD,HahnWCandXuW.*(2007).StructuralbasisofPP2Ainhibitionbysmalltantigen.PLoSBiology,5,1810-1819. 14.SampietroS,DahlbergCL,ChoUS,HindsTR,KimelmanD,andXuW.*(2006).CrystalStructureofab-catenin/BCL9/Tcf4Complex.MolecularCell,24,293-300. 15.XingY,ClementsWK,LeTrongI,HindsTR,StenkampR,KimelmanDandXuW.*(2004).Crystalstructureofab-catenin/APCcomplexrevealsacriticalroleforAPCphosphorylationinAPCfunction.MolecularCell.15,523-533.(coverstory). 16.XingY,ClementsWK,KimelmanD,andXuW.*(2003).Crystalstructureofabeta-catenin/Axincomplexsuggestsamechanismforthebeta-catenindestructioncomplex.GenesandDevelopment,17,2753-2764.(coverstory). 17.GrahamT,ClementsW,KimelmanD,andXuW.*(2002).Crystalstructureofthebeta-catenin/ICATcomplexrevealsainhibitorymechanismofWntsignalingpathway.MolecularCell,10,563-571. 18.GrahamT,FerkeyD,MaoF,KimelmanD,andXuW.*(2001).Tcf4canspecificallyrecognizebeta-cateninusingalternativeconformations.NatureStructureBiology,8,1048-1052. 19.XuW,HarrisonSC,andEckMJ*(1997).Three-dimensionalstructureofthetyrosinekinasec-Src.Nature,385,595-602.(Article) 20.XuW,RouldMA,JunS,DesplanC,andPaboCO*(1995).Crystalstructureofapaireddomain-DNAcomplexat2.5ÅresolutionrevealsstructuralbasisforPaxdevelopmentalmutations.Cell,80,639-650