个人简介

Professor of Chemistry. B. A., 1986, Texas A&M University. Ph. D., 1991, Colorado State University. American Cancer Society Postdoctoral Fellow, 1991-93, Harvard University. Organic Chemistry. Structure elucidation, total synthesis, and mode of actions studies of physiologically active natural products; synthetic methodology including asymmetric catalysis

研究领域

Bioorganic Chemistry/Synthesis

Total Synthesis and Biomechanistic Studies of Marine Natural Products β-Lactones: Novel Synthetic Targets, Enzyme Inhibitors, and Vehicles for Synthesis New Methods for Simultaneous Arming and SAR Studies of Natural Products and Subsequent Cellular Receptor Isolation

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

"Facile Sythesis of the Trans-Fused Azabicyclo [3.3.0] Octane Core of Palau'amine and the Tricyclic Core of Axinellamine from a Common Intermediate" Zancanella, M. A.; Romo, D. Org. Lett. 2008, ASAP. "Concise Synthesis of Spirocyclic, Bridged γ-Butrolactones via Stereospecific, Dyotropic Rearrangements of β-Lactones Involving 1,2-Acyl and δ-Lactone Migrations" Purohit, V. C.; Matla, A. S.; Romo, D. J. Am. Chem. Soc. 2008,130, 10478-10479. "Highly Diastereoselective, Tandem, Three-Component Synthesis of Tetrahydrofurans from Ketoaldehydes via Silylated β-Lactone Intermediates: Application to a Colpsinol B Fragment" Mitchell, T. A.; Zhao, C.; Romo, D. Angew. Chem. Int. Ed. 2008, 47, 5026-5029. "β-Lactam Congeners of Orlistat as Inhibitors of Fatty Acid Synthase" Zhang, W.; Richardson, R. D.; Chamni, S.: Smith, J. W.; Romo, D. Bioorg. Med. Chem. Lett. 2008, 28, 2491-2494. (Featured in Chemical & Engineering News, "Fat Chance to Cure Cancer", June 23, 2008) "Enantioselective Synthesis of (+) Monobromophakellin and (+)-Phakellin: A Concise Phakellin Annulation Strategy Applicable to Palau'amine" Wang, S.; Romo, D. Angew. Chem. Int. Ed. 2008, 47, 1284-1286. (Highlighted in Synfacts 2008, 7, 678) "Simultaneous Arming and Structure/Activity Studies of Natural Products Employing O-H Insertions: An Expedient and Versatile Strategy for Natural Products-Based Chemical Genetics" Peddibhotla, S.; Dang, Y.; Liu, J. O.; Romo, D. J. Am. Chem. Soc., 2007, 129, 12222-12231. (Featured in Chemical & Engineering News, "Tagging Natural Products", October 1, 2007) "Substrate-Dependent Targeting of Eukaryotic Translation Initiation Factor 4A by Pateamine A: Negation of Domain-Linker Regulation of Activity" Low, W.-K.; Dang, Y.; Bhat, S.; Romo, D.; Liu, J. O. Chem. & Biol. 2007, 14, 1-13. "Concise Total Synthesis of (+/-)- Salinosporamide A, (+/-)-Cinnabaramide A, and Derivatives via a Bis-Cyclization Process: Implications for a Biosynthetic Pathway?" Ma, G.; Nguyen, H.; Romo, D. Org. Lett. 2007, 9, 2143-2146. (Highlighted in Synfacts 2007, 10, 1014) "Total Synthesis of Belactosin C and Congeners via the Tandem Mukaiyama Aldol-Lactonization Process" Cho, S. W.; Romo, D. Org. Lett. 2007, 9, 1537-1540. (Highlighted in Synfacts 2007, 8, 789) "Isolation and Identification of Eukaryotic Initiation Factor 4A as a Molecular Target for the Marine Natural Product Pateamine A" Low, W.-K.; Dang, Y.; Schneider-Poetsch, T.; Shi, Z.; Choi, N. S.; Rzasa, R. M.; Shea, H. A.; Li, S.; Park, K.; Ma, G.; Romo, D.; Liu, J. O. Methods in Enzymology 2007, 431, 303-0324. "Eukaryotic Initiation Factor 2α-independent Pathway of Stress Granule Induction by the Natural Product Pateamine A" Dang Y.; Kedersha, N.; Low, W.-K.; Romo, D.; Gorospe, M.; Kaufman, R.; Anderson, P.; Liu, J. O. J. Biol. Chem. 2006, 281, 32870-32878. "Synthesis, Characterization, and Utility of Thermoresponsive Natural/Unnatural Product Macroligands for Affinity Chromatography" Zhou, M.; Sivaramakrishnan, A.; Ponnamperuma, K.; Low, W.-K.; Li, C.; Zhang, Y.; Liu, J. O.; Bergbreiter, D.; Romo, D. Org. Lett. 2006, 8, 5247-5250. "Bicyclic and Tricyclic-β-Lactones via an Organonucleophile Bis-cyclization of Keto-Acids: Enantioselective Synthesis of (+)-Dihydroplakevulin" Henry-Riyad, H.; Lee, C. S.; Purohit, V.; Romo, D. Org. Lett. 2006, 8, 4363-4366. "Practical, Catalytic, Asymmetric Synthesis of β-Lactones via a Sequential Ketene Dimerization/Hydrogenation Process: Inhibitors of the Thioesterase Domain of Fatty Acid Synthase" Purohit, V. C.; Richardson, R. D., Smith, J. W.; Romo, D. J. Org. Chem. 2006, 71, 4549-4558.