个人简介

Distinguished Professor of Chemistry and Davidson Professor of Science. B. A., 1972, St. Thomas College. Ph. D., 1976, University of Wisconsin Madison. Postdoctoral Fellow, 1976-80, Pennsylvania State University. Biochemistry. Determination of enzyme reaction mechanisms and protein structure using kinetic, genetic, and magnetic resonance techniques.

研究领域

Bioinorganic Chemistry/Bioorganic Chemistry/Catalysis/Molecular Structure

Elucidation of Enzyme Catalyzed Reaction Mechanisms Design and Evolution of Novel Enzymes Discovery and Annotation of Enzymes of Unknown Function

近期论文

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P.-C. Tsai, N. Fox, A. N. Bigley, S. P. Harvey, D. P. Barondeau, and F. M. Raushel, "Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents" Biochemistry 51, 6463-6475 (2012). S. S. Kamat, H. J. Williams, and F. M. Raushel, "Intermediates in the Transformation of Phosphonates to Phosphate in Bacteria" Nature 480, 570-573 (2011). F. M. Raushel, "Catalytic Detoxification" Nature, 469, 310-311 (2011). A. M. Goble, H. Fan, A. Sali, and F. M. Raushel, "The Discovery of a Cytokinin Deaminase" ACS Chemical Biology, 6, 1036-1040 (2011). S. Kamat, H. Fan, J. M. Sauder, S. K. Burley, B. K. Shoichet, A. Sali, and F. M. Raushel, "Enzymatic Deamination of the Epigenetic Base N-6-Methyladenine" Journal of the American Chemical Society, 133, 2080-2083 (2011). J. Hermann, R. Marti-Arbona, E. Fedorov, A. Fedorov, S. Almo, B. K. Shoichet, and F. M. Raushel, "Structure-Based Activity Prediction for an Enzyme of Unknown Function" Nature, 448, 775-779 (2007). R. S. Hall, A. A. Fedorov, R. Marti-Arbona, E. V. Fedorov, P. Kolb, J. M. Sauder, S. K. Burley, B. K. Shoichet, S. C. Almo, and F. M. Raushel, "The Hunt for 8-Oxoguanine Deaminase" Journal of the American Chemical Society 132, 1762-1763 (2010). D. S. Hitchcock, A. A. Fedorov, E. V. Fedorov, L. Dangott, S. C. Almo, and F. M. Raushel, "Rescue of the Orphan Enzyme Isoguanine Deaminase", Biochemistry 50, 5555-5557 (2011).