Alexanian, Erik - The University of North Carolina at Chapel Hill

个人简介

EDUCATION Ph.D. Organic Chemistry; Princeton University, Princeton, NJ 2006 A.B. cum laude in Chemistry; Harvard University, Cambridge, MA 2001 High School graduation; Boston Latin School, Boston, MA 1997 APPOINTMENT Professor of Chemistry, 2019 – present University of North Carolina, Chapel Hill, NC EXPERIENCE University of North Carolina, Chapel Hill, NC:Associate Professor 2017 – 2019 Associate Professor of Chemistry and Director of Undergraduate Studies 2014 – 2017 Assistant Professor of Chemistry 2008 – 2014 University of Illinois at Urbana-Champaign, Urbana, IL 2006 – 2008 and Yale University, New Haven, CT: Postdoctoral Research with Professor John F. Hartwig; Synthetic and Mechanistic Studies of Transition Metal Enolates Princeton University, Princeton, NJ 2001 – 2006 and The Scripps Research Institute, La Jolla, CA:Graduate Research with Professor Erik J. Sorensen;Synthesis of the Furanosteroid Viridin and New Metal-Catalyzed Alkene Difunctionalizations Boston College, Chestnut Hill, MA: 1999 – 2001 Undergraduate Research with Professor Amir Hoveyda;Molybdenum-Catalyzed Enantioselective Alkene Metathesis

研究领域

Research in our group focuses on the development of enabling reaction methods in chemical synthesis. These projects aim to address important challenges facing society, ranging from the sustainable synthesis of small molecules to treat human disease, to the upcycling of post-consumer plastic waste. A primary focus is the late-stage functionalization of unactivated C–H bonds in both small molecules and polymers to efficiently access complex molecules and materials with enhanced properties. We also pursue the development of new modes of reactivity in transition metal catalysis, with an emphasis on the use of common molecular feedstocks and earth-abundant first-row catalysts.

近期论文

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Cobalt-Catalyzed Synthesis of Amides from Alkenes and Amines Promoted by Light. Mason S. Faculak, Alexander M. Veatch, and Erik J. Alexanian. Science 2024, 383, 77-81 C–H Functionalization of Polyolefins to Access Reprocessable Polyolefin Thermosets. Eliza K. Neidhart, Mutian Hua, Zhengxing Peng, Logan T. Kearney, Vittal Bhat, Foad Vashahi, Erik J. Alexanian, Sergei S. Sheiko, Cheng Wang, Brett A. Helms, and Frank A. Leibfarth. J. Am. Chem. Soc. 2023, 145, 50, 27450–27458 General Synthesis of N-Alkylindoles from N,N-Dialkylanilines via [4 + 1] Annulative Double C–H Functionalization. Bowen Zhang, Frederik R. Erb, Aristidis Vasilopoulos, Eric A. Voight, and Erik J. Alexanian. J. Am. Chem. Soc. 2023, 145, 49, 26540–26544 Modifying Poly(caprolactone) Degradation through C–H Functionalization. Victoria J. Barber, Meredith A. Borden, Jill W. Alty, Ly D. Tran, Hilmar Koerner, Luke A. Baldwin, Erik J. Alexanian, and Frank A. Leibfarth. Macromolecules 2023, 56, 10, 3679–3686 Cobalt-Catalyzed Deaminative Amino- and Alkoxycarbonylation of Aryl Trialkylammonium Salts Promoted by Visible Light. Alexander Veatch, Shubin Liu, Erik John Alexanian. Angew. Chem. Int. Ed. 2022, 61, e202210772 Heteroarylation of unactivated C–H bonds suitable for late-stage functionalization. Austin S. Miller, Erik J. Alexanian. Chem. Sci. 2022, 13, 11878-11882 Diversification of aliphatic C–H bonds in small molecules and polyolefins through radical chain transfer. Timothy J. Fazekas, Jill W. Alty, Eliza K. Neidhart, Austin S. Miller, Frank A. Leibfarth, Erik J. Alexanian. Science 2022, 375, 545-550 Stereospecific Nickel-Catalyzed Reductive Cross-Coupling of Alkyl Tosylate and Allyl Alcohol Electrophiles. Quentin D. Tercenio, Erik J. Alexanian. Org. Lett. 2021, 23, 7215-7219 Cobalt-catalyzed Aminocarbonylation of (Hetero)aryl Halides Promoted by Visible Light. Alexander M. Veatch, Erik J. Alexanian. Chem. Sci. 2020, 11, 7210-7213 Direct Decarboxylative Functionalization of Carboxylic Acids via O-H Hydrogen Atom Transfer. Christina G. Na, Davide Ravelli, Erik J. Alexanian. J. Am. Chem. Soc. 2020, 142, 44-49 Manganese-Catalyzed Stereospecific Hydroxymethylation of Alkyl Tosylates. Hannah Shenouda, Erik J. Alexanian. Org. Lett. 2019, 21, 9268-9271 Identifying Amidyl Radicals for Intermolecular C-H Functionalizations. Special Issue on C-H Bond Functionalization. Matthew M. Tierney, Stefano Crespi, Davide Ravelli, Erik. J. Alexanian. J. Org. Chem. 2019, 84, 12983-12991 C-H Alkylation via Multisite Proton-Coupled Electron Transfer of an Aliphatic C-H Bond. Carla M. Morton, Qilei Zhu, Hunter Ripberger, Ludovic Troian-Gautier, Zi S. D. Toa, Robert R. Knowles, Erik J. Alexanian. J. Am. Chem. Soc. 2019, 141, 13253-13260 Chemo- and Regioselective Functionalization of Isotactic Polypropylene: A Mechanistic and Structure-Property Study. Jill B. Williamson, Christina G. Na, Robert R. Johnson III, William F. M. Daniel, Erik J. Alexanian, Frank A. Leibfarth. J. Am. Chem. Soc. 2019, 141, 12815-12823 Nickel-Catalyzed, Ring-Forming Aromatic C-H Alkylations with Unactivated Alkyl Halides. Special Issue in honor of Prof. John Hartwig’s 2018 Tetrahedron Prize. Quentin D. Tercenio, Erik J. Alexanian. Tetrahedron 2019, 75, 4143-4149 Cobalt-Catalyzed Aminocarbonylation of Alkyl Tosylates: Stereospecific Synthesis of Amides. Brendon T. Sargent, Erik J. Alexanian. Angew. Chem. Int. Ed. 2019, 58, 9533-9536 Transition-Metal (Pd, Ni, Mn)-Catalyzed C-C Bond Constructions Involving Unactivated Alkyl Halides and Fundamental Synthetic Building Blocks. Megan R. Kwiatkowski, Erik. J. Alexanian. Acc. Chem. Res. 2019, 52, 1134-1144 Nickel-Catalyzed Mizoroki-Heck-Type Reactions of Unactivated Alkyl Bromides. Megan R. Kwiatkowski, Erik J. Alexanian. Angew. Chem. Int. Ed. 2018, 57, 16857-16860 A General Approach to Site-Specific, Intramolecular C-H Functionalization Using Dithiocarbamates. Christina G. Na, Erik J. Alexanian. Angew. Chem. Int. Ed. 2018, 57, 13106-13109 Reagent-Dictated Site Selectivity in Intermolecular Aliphatic C-H Functionalizations Using Nitrogen-Centered Radicals. Anthony M. Carestia, Davide Ravelli, Erik J. Alexanian. Chem. Sci. 2018, 9, 5360-5365 Regioselective C-H Xanthylation as a Platform for Polyolefin Functionalization. Jill B. Williamson, William L. Czaplyski, Erik J. Alexanian, Frank A. Leibfarth. Angew. Chem. Int. Ed. 2018, 57, 6261-6265 A General Strategy for Aliphatic C-H Functionalization Enabled by Organic Photoredox Catalysis. Kaila A. Margrey, William L. Czaplyski, David A. Nicewicz, Erik J. Alexanian. J. Am. Chem. Soc. 2018, 140, 4213-4217 Cobalt-Catalyzed Carbonylative Cross-Coupling of Alkyl Tosylates and Dienes: Stereospecific Synthesis of Dienones at Low Pressure. Brendon T. Sargent, Erik J. Alexanian. J. Am. Chem. Soc. 2017, 139, 12438-12440 Palladium-Catalyzed Carbocyclizations of Unactivated Alkyl Bromides with Alkenes Involving Auto-tandem Catalysis. Alexander R. O. Venning, Megan R. Kwiatkowski, Joan E. Roque Pena, Brendan C. Lainhart, Akil A. Guruparan, Erik J. Alexanian. J. Am. Chem. Soc. 2017, 139, 11595-11600 Cobalt-Catalyzed Silylcarbonylation of Unactivated Secondary Alkyl Tosylates at Low Pressure. Joan E. Roque Pena, Erik J. Alexanian. Org. Lett. 2017, 19, 4413-4415 A General Approach to Quaternary Center Construction from Couplings of Unactivated Alkenes and Acyl Xanthates. Ernest N. Jenkins, William L. Czaplyski, Erik J. Alexanian. Org. Lett. 2017, 19, 2350-2353