Kohn, Harold - The University of North Carolina at Chapel Hill

个人简介

Dr. Kohn received a BS in Chemistry from the University of Michigan in 1966, and a PhD in Chemistry from Pennsylvania State University in 1971. He conducted postdoctoral research at Columbia University from 1971-1973 with Professor Ronald Breslow. Dr. Kohn then joined the faculty at the University of Houston in 1973 before coming to the University of North Carolina in 1999.

研究领域

Examination of the biological mechanism of mitomycin C and bicyclomycin at the molecular level; design and synthesis of new chemotherapeutic agents for the treatment of epilepsy, cancer, and bacterial infections

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Myoung Goo Kim, Ulrich Strych, Kurt Krause, Michael Benedik, and Harold Kohn,* Evaluation of Amino-Substituted Heterocyclic Derivatives as Alanine Racemase Inhibitors, Med. Chem. Res., 12, 130-138 (2003). Edwin Vedejs,* B.N. Naidu, Artis Klapars, Don L. Warner, Ven-Shun Li, Younghwa Na, and Harold Kohn,* Synthetic Enantiopure Aziridinomitosenes; Preparation, Reactivity, and DNA Alkylation Studies, J. Am. Chem. Soc., 125, 15796-15806 (2003). Sang Hyup Lee and Harold Kohn,* Cyclic Disulfide C(8) Iminoporfiromycin: Nucleophilic Activation of a Porfiromycin, J. Am. Chem. Soc., 126, 4281-4292 (2004). Cécile Béguin, Arnaud LeTiran, James P. Stables, and Harold Kohn,* N-Substituted Amino Acid N'-Benzylamides: Synthesis, Anticonvulsant and Metabolic Activities, Bioorg. Med. Chem., 12, 3079-3096 (2004). Myoung Goo Kim, Erik T. Bodor, T. Kendall Harden,* and Harold Kohn,* C(8) Substituted 1-Azabicyclo[3.3.1]non-3-enes: A Novel Scaffold for Muscarinic Receptor Ligands, Bioorg. Med. Chem., 12, 2357-2367 (2004). Min Shen, Cécile Béguin, Alexander Golbraikh, James P. Stables, Harold Kohn* and Alexander Tropsha,* Application of Predicitive QSAR Models to Database Mining: Rational Discovery of Novel Anticonvulsant Lead Compounds, J. Med. Chem., 47, 2356-2364 (2004). Emmanuel Skordalakes, Andrew P. Brogan, Boon Saeng Park, Harold Kohn, and James M. Berger,* Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin, Structure, 13, 99-109 (2005). Sang Hyup Lee and Harold Kohn,* 7-N,7'-N'-(1'',2''-Dithanyl-3'',6''-dimethylenyl)bismitomycin C: Synthesis and Nucleophilic Activation of a Dimeric Mitomycin, Organic & Biomolecular Chemistry, 3, 471-482 (2005). Andrew P. Brogan, William R. Widger,* Dalila Bensadek, Isabel Riba-Garcia, Simon J. Gaskell* and Harold Kohn,* Development of a Technique to Determine Bicyclomycin-Rho Binding and Stoichiometry by Isothermal Titration Calorimetry and Mass Spectrometry, J. Am. Chem. Soc. 127, 2741-2751 (2005). Sang Hyup Lee, Robert L. Brodnick, Gary L. Glish, and Harold Kohn,* 3,8,11,16-Tetrakis(aminomethyl)-1,2,9,10-tetrathiacyclohexadecane Tetra-trifluoroacetic Acid: Synthetic Precursor to a Novel Thio-Substituted Diamine, Tetrahedron, 61, 1749-1754 (2005). Andrew P. Brogan, Jacob Verghese, William R. Widger*, and Harold Kohn,* Bismuth-dithiol inhibition of the Escherichia coli rho transcription termination factor, J. Inorg. Biochem., 99, 841-851 (2005). Pierre LeMagueres, Hookang Im, Jerry Ebalunode, Ulrich Strych, Michael Benedik, James Briggs, Harold Kohn and Kurt L. Krause,* The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved passageway into the active sites, Biochemistry, 44, 1471-1481 (2005). Harold Kohn* and William Widger*, The Molecular Basis for the Mode of Action of Bicyclomycin, Current Drug Targets: Infect. Disord. 5, 273-295 (2005). Albert Y. Jin, Harold Kohn, Cécile Béguin, Shridhar V. Andurkar, James P. Stables, and Donald F. Weaver,* A Quantitative Structure-Activity Relationship Study for -Substituted Acetamido-NHarol Benzylacetamide Derivatives: A Novel Anticonvulsant Drug Class, Can. J. Chem., 83, 37-45 Gary E. Duncan* and Harold Kohn, The Novel Antiepileptic Drug Lacosamide Blocks Behavioral and Brain Metabolic Manifestations of Seizure Activity in the 6 Hz Psychomotor Seizure Model, Epilepsy Res. 67, 81-87 (2005). Boon Sang Park, William R. Widger, and Harold Kohn,* Fluorine-substituted Dihydrobicyclomycins: Synthesis, Biochemical and Biological Properties, Bioorg. Med. Chem. 14, 41-61 (2006).