个人简介

Princeton University, B. A., 1956; Oxford University B. A. (1958), M. A. (1960); Rockefeller Institute, Ph.D. (1964); NIH Research Career Development Award (1971-1976); Fellow, American Association for the Advancement of Science (1983); Member, Editorial Board, Bioorganic Chemistry (1983-); North Carolina Distinguished Chemist Award, ACS (1990);Member, Editorial Board, Bioorganic and Medicinal Chemistry and Bioorganic and Medicinal Chemistry Letters (1989-) Chairman, Biological Division, American Chemical Society (2000-); Elected, Member of National Academy of Sciences (2002); Elected, Fellow of American Academy of Arts and Sciences (2002)

研究领域

Biochemistry & Chemical Biology

Kinetics of Enzymatic Reactions

近期论文

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Edwards, D. R., Lohman, D. C., Wolfenden, R., Catalytic proficiency: the extreme case of S-O cleaving sulfatases, J. Am. Chem. Soc. 134, 525-531, 2012 Wolfenden, R., Benchmark reaction rates, the stability of biological molecules in water, and the evolution of catalytic power in enzymes, Ann. Rev. Biochem. 80, 645-667, 2011 Stockbridge, R. B.; Lewis, C. A., Jr.; Yuan, Y., Wolfenden, R., Impact of temperature on the time required for the establishment of primordial biochemistry, and for the evolution of enzymes, Proc. Nat. Acad Sci. U. S. A. 107, 22102-22105, 2010 Stockbridge, R.; Wolfenden, R., Phosphate monoester hydrolysis in cyclohexane, J. Am. Chem. Soc. 131, 18248-18249, 2009 Schroeder, G. K., Wolfenden, R., Rates of Spontaneous Disintegration of DNA, and the Catalytic Proficiencies of DNA Glycosylases and Deaminases, Biochemistry 46, 16368-16347, 2007 Wolfenden, R., Degrees of Difficulty of Water-Consuming Reactions in the Absence of Enzymes, Chemical Reviews 106, 3379-3396, 2006 Horvat, C. M., Wolfenden, R. V., A Persistent Pesticide Residue and the Unusual Catalytic Proficiency of a Dehalogenating Enzyme, Proc. Natl. Acad. Sci. U. S. 102, 16199-16202, 2005 Callahan, B. P., Wolfenden, R., The Burden Borne by Urease, J. Am. Chem. Soc. 127, 10828-10829, 2005 Borchers, C. Marquez, V. E., Schroeder, G. K., Short, S. A., Snider, M. J., Speir, J. P., Wolfenden, R. Fourier, Transform Ion Cyclotron Resonance MS Reveals the Presence of a Water Molecule in an Enzyme Transition-State Analogue Complex, Proc. Natl. Acad. Sci. U. S. 101, 15341-15345, 2004 Sievers, A., Beringer, M., Rodnina, M. V., Wolfenden, R., The Ribosome as an Entropy Trap, Proc. Natl. Acad. Sci. U. S. 101, 7897-7901, 2004