个人简介

Fulbright Scholar, Universitaet Goettingen, Germany (1987), Yale University, Ph.D. (1992). Jane Coffin Childs Postdoctoral Fellow, University of Colorado (1992-1996); Research Innovation Award, Research Corporation (1997); Searle Scholar in the Biomedical Sciences (1998-2001); NSF Career Award (2000-2005); Visiting Scholar, National Institutes of Health, NIEHS (2002-2003); North Carolina Health & Life Sciences Promise for Tomorrow Award (2009); NIH EUREKA Award (2011-2015); Fellow, American Association for the Advancement of Science (2012); Kenan Senior Faculty Competitive Research and Scholarly Leave (2013); Life Member, Clare Hall, University of Cambridge, UK (2014)

研究领域

Biochemistry & Chemical Biology

Structural and Chemical Biology of the Transcriptome

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

K.M. Weeks, RNA clubs. RNA 21, 760-761 (2015). D.M. Mauger, M. Golden, D. Yamane, S. Willford, S.M. Lemon, D.P. Martin and K.M. Weeks, The functionally conserved architecture of hepatitis C virus RNA genomes. Proc. Natl. Acad. Sci. USA 112, in press (2015). J.L. McGinnis, Q. Liu, C.A. Lavender, A. Devaraj, S.P. McClory, K. Fredrick and K.M. Weeks, In-cell SHAPE reveals that free 30S ribosome subunits are in the inactive state. Proc. Natl. Acad. Sci. USA 112, 2425-2430 (2015). link data C.A. Lavender, R.J. Gorelick and K.M. Weeks, Structure-based alignment and consensus secondary structures for three HIV-related RNA genomes. PLoS Comp. Biol. 11, in press (2015). C.A. Lavender, R. Lorenz, G. Zhang, R. Tamayo, I.L. Hofacker and K.M. Weeks, Model-free RNA sequence and structure alignment informed by SHAPE probing reveals a conserved alternative secondary structure for 16S rRNA. PLoS Comp. Biol. 11, in press (2015). K.M. Weeks, Toward all RNA structures, concisely. Biopolymers 103, in press (2015). link A.I. Taylor, V.B. Pinheiro, M.J. Smola, A.S. Morgunov, S. Peak-Chew, C. Cozens, K.M. Weeks, P. Herdewijn & P. Holliger, Catalysts from synthetic genetic polymers. Nature 518, 427-430 (2015). link P.J. Homan, A. Tandon, G.M. Rice, F. Ding, N.V. Dokholyan and K.M. Weeks, RNA tertiary structure analysis by 2'-hydroxyl molecular interference. Biochemistry 53, 6825-6833 (2014). link P.J. Homan, O.V. Favorov, C.A. Lavender, O. Kursun, X. Ge, S. Busan, N.V. Dokholyan and K.M. Weeks, Single-molecule correlated chemical probing of RNA. Proc. Natl. Acad. Sci. USA 111, 13858-13863 (2014). N.A. Siegfried, S. Busan, G.M. Rice, J.A.E. Nelson and K.M. Weeks, RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP). Nature Meths. 11, 959-965 (2014). J.T. Low, P. Garcia-Miranda, K.D. Mouzakis, R.J. Gorelick, S.E. Butcher and K.M. Weeks, Structure and dynamics of the HIV-1 frameshift element RNA. Biochemistry 53, 4282-4291 (2014). G.M. Rice, S. Busan, F. Karabiber, O.V. Favorov and K.M. Weeks, SHAPE analysis of small RNAs and riboswitches. Methods Enzymol. 549, 165-187 (2014). J.L. McGinnis and K.M. Weeks, Ribosomal RNA assembly intermediates visualized in living cells. Biochemistry 53, 3237-3247 (2014). K.D. Warner, P. Homan, K.M. Weeks, A.G. Smith, C. Abell & A.R. Ferré-D'Amaré, Validating fragment-based drug discovery for biological RNAs: Lead fragments bind and remodel the TPP riboswitch specifically. Chem. Biol. 21, 591-595 (2014). J.K. Grohman, R.J. Gorelick, S. Kottegoda, N.L. Allbritton, A. Rein and K.M. Weeks, An immature retroviral RNA genome resembles a kinetically trapped intermediate state. J. Virol. 88, 6061–6068 (2014). G.M. Rice, C.W. Leonard and K.M. Weeks, RNA secondary structure modeling at consistent high accuracy using differential SHAPE. RNA 20, 846-854 (2014). J. Tyrrell, J.L. McGinnis, K.M. Weeks and G.J. Pielak, The cellular environment stabilizes adenine riboswitch RNA structure. Biochemistry 52, 8777-8785 (2013). S. Busan and K.M. Weeks, The role of context in RNA structure: flanking sequences reconfigure CAG motif folding in huntingtin exon 1 transcripts. Biochemistry 52, 8219-8225 (2013). E.J. Archer, M.A. Simpson, N.J. Watts, R. O'Kane, B. Wang, D.A. Erie, A. McPherson and K.M. Weeks, Long-range architecture in a viral RNA genome. Biochemistry 52, 3182-3190 (2013). E. Pollom, K.K. Dang, E.L. Potter, R.J. Gorelick, C.L. Burch, K.M. Weeks and R. Swanstrom, Comparison of SIV and HIV-1 genomic RNA structures reveals impact of sequence evolution on conserved and non-conserved structural motifs. PLoS Path. 9, e1003294 (2013). D.M. Mauger, N.A. Siegfried and K.M. Weeks, The genetic code as expressed through relationships between mRNA structure and protein function. FEBS Lett. 587, 1180-1188 (2013). C.E. Hajdin, S. Bellaousov, W. Huggins, C.W. Leonard, D.H. Mathews and K.M. Weeks, Accurate SHAPE-directed RNA secondary structure modeling, including pseudoknots. Proc. Natl. Acad. Sci. USA 110, 5498-5503 (2013). J.K. Grohman, R.J. Gorelick, C.R. Lickwar, J.D. Lieb, B.D. Bower, B.M. Znosko and K.M. Weeks, A guanosine-centric mechanism for RNA chaperone function. Science 340, 190-195 (2013). S. Ramachandran, F. Ding, K.M. Weeks and N.V. Dokholyan, Statistical analysis of SHAPE-directed RNA secondary structure modeling. Biochemistry 52, 596-599 (2013). C.W. Leonard, C.E. Hajdin, F. Karabiber, D.H. Mathews, O.V. Favorov, N.V. Dokholyan and K.M. Weeks, Principles for understanding the accuracy of SHAPE-directed RNA structure modeling. Biochemistry 52, 588-595 (2013). F. Karabiber, J.L. McGinnis, O.V. Favorov and K.M. Weeks, QuShape: Rapid, accurate and best-practices quantification of nucleic acid probing information, resolved by capillary electrophoresis. RNA 19, 63–73 (2013).