贾宗超 - 北京师范大学

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K.Klupt and Z. Jia (2023). eEF2K inhibitor design: The progression of exemplary structure-based drug design. Molecules, 8:1095. B. Guo, F. Chou, L. Huang, F. Yin, J. Fang, J. Wang and Z. Jia. (2022) Recent insights into oxidative metabolism of quercetin: catabolic profiles, degradation pathways, catalyzing metalloenzymes and molecular mechanisms. Crit. Rev. Food Sci. Nutr. doi:10.1080/10408398.2022.2115456 B. Wang, H. Pei, Z. Lu, Y. Xu, S. Han, Z. Jia and J. Zheng. (2022). YihE is a novel binding partner of Rho and regulates Rho-dependent transcription termination in the Cpx stress response. iScience, 25:105483. Y.-M. She, K. Klupt, G. Hatfield, Z. Jia and R.Y. Tam. (2022) Unusual beta1-4-galactosidase activity of an alpha1-6-mannosidase from Xanthamonas manihotis in the processing of branched hybrid and complex glycans. J. Biol. Chem. 298:102313. Z. Qiu, S. Hao, S. Song, R. Zhang, T. Yan, Z. Lu, H. Wang, Z. Jia and J. Zheng. (2022) PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP. Front. Cell Dev. Biol. 10:902403. N. Neville, N. Roberge and Z. Jia. (2022) Polyphosphate kinase 2 (PPK2) enzymes: structure, function, and roles. Int. J. Mol. Sci. 23:670. Z. Lu, B. Wang, Z. Qiu, R. Zhang, J. Zheng and Z. Jia. (2022) YdfD, a lysis protein of the Qin prophage, is a specific inhibitor of the IspG-catalysed step in the MEP pathway of Escherichia coli. Int. J. Mol. Sci. 23:1560. N. Roberge, N. Neville, K. Douchant, C. Noordhof, N. Boev, C. Sjaarda, P.M Sheth and Z. Jia. (2021) Broad-spectrum inhibitor of bacterial polyphosphate homeostasis attenuates virulence factors and helps reveal novel physiology of K. pneumoniae and A. baumannii. Front. Microbiol. 12:764733. N. Neville, N. Roberge, X. Ji, P. Stephen, L.J. Lu and Z. Jia. (2021) A dual-specificity inhibitor targets polyphosphate kinase 1 and 2 enzymes to attenuate virulence of Pseudomonas aeruginosa. mBio 12:e00592-21. W. Wu, Zheng and Z. Jia. (2021) Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation. iScience, 4:102895. C.E. Miron, L. van Staalduinen, A.M. Rangaswamy, M. Chen, Y. Liang, Z. Jia, J.-L. Mergny and A. Petitjean. (2021) Going platinum to the tune of a remarkable guanine quadruplex binder: Solution- and solid-state investigations. Angew Chem Int Ed. 60, 2500-2507. J. J. Carson, C. E. Miron, J. Luo, L. van Staalduinen, Z. Jia and A. Petitjean. (2021) Exploration of head-to-tail and head-to-head isomers of a guanine quadruplex platinum-based binder. Inorganica Chim Acta, 518:120236. W. Wu, Q. Shen, R. Zhang, Z. Qiu, Y. Wang, J. Zheng and Z. Jia. (2020) The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter. EMBO J. 39:e104285. Z. Lei, B. Wang, Z. Lu, N. Wang, H. Tan, J. Zheng and Z. Jia. (2020) New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development. FEBS J. 287, 3579-3599. C. Yuan, Y. Zhang, H. Tan, X. Li, G. Chen and Z. Jia. (2020) ONIOM investigations of heme degradation mechanism by MhuD: the critical function of heme ruffling. Phys. Chem. Chem. Phys. 22, 8817-8826. Y. Zhang, S. Wang and Z. Jia. (2020) In situ proteolysis condition-induced crystallization of the XcpVWX complex in different lattices. Int. J. Mol. Sci. 21:308. Z. Lei, N. Wang, H. Tan, J. Zheng and Z. Jia. (2020) Conformational plasticity of the active site entrance in E. coli aspartate transcarbamoylase and its implication in feedback regulation. Int. J. Mol. Sci. 21:320. W. Wu, Q. Shen, Z. Lei, Z. Qiu, D. Li, H. Pei, J. Zheng and Z. Jia. (2019) The crystal structure of MICU2 provides insight into Ca2+-binding and MICU1-MICU2 heterodimer formation. EMBO Rep. 20:e47488. B. Guo, Y. Zhang, G. Hicks, X. Huang, R. Li, N. Roy and Z. Jia. (2019) Structure-dependent modulation of substrate binding and biodegradation activity of Pirin proteins towards plant flavonols. ACS Chem. Biol. 14, 2629-2640. D. Vukomanovic, Z. Jia, K. Nakatsu, G. Smith and T. Ozolins. (2019) Riboflavin and pyrroloquinoline quinone generate carbon monoxide in the presence of tissue microsomes or recombinant human cytochrome P-450 oxidoreductase (CPR); implications for possible roles in gasotransmission. Can. J. Physiol. Pharmacol. 98, 336-342. X. Zhang, Q. Shen, Z. Lei, Q. Wang, J. Zheng and Z. Jia.(2019) Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation.Sci. Rep. 9:9198. N. Neville and Z. Jia.(2019) Approaches to the structure-based design of antivirulence drugs: Therapeutics for the post-antibiotic era. Molecules, 24:378. W. Wu, J. Zheng and Z. Jia. (2018) Expression and characterization of MICU2, a Ca2+ sensor protein. Methods Mol. Biol. 1929, 261-273. Q. Yang, M. Zhang, J. Zheng and Z. Jia. (2019) AtNPR4 from Arabidopsis thaliana: expression, purification, crystallization and crystallographic analysis. Acta Cryst. F75, 67-72. Y. Zhang, F. Faucher, W. Zhang, S. Wang, N. Neville, K. Poole, J. Zheng and Z. Jia. (2018) Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa. PLoS Pathog. 14:e1007343. M.B. Connell, M.J.Y. Lee, J. Li, W.C. Plaxton and Z. Jia. (2018) Structural and biochemical characterization of citrate binding to AtPPC3, a plant-type phosphoenolpyruvate carboxylase from Arabidopsis thaliana. J. Struct. Biol. 204, 507-512. Q. Shen, Z. Qiu, W. Wu, J. Zheng and Z. Jia. (2018) Characterization of interaction and ubiquination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5. Biol Open, 7:bio037366 G. Hicks and Z. Jia. (2018) Structural basis for the lipopolysaccharide export activity of the bacterial lipopolysaccharide transport system. Int. J. Mol. Sci. 19:2680. M.N. Rahman, D. Vukomanovic, J.Z. Vlahakis, W.A. Szarek, K. Nakatsu and Z. Jia. (2018) Structural insights into azole-based inhibitors of heme oxygenase-1: Development of selective compounds for therapeutic applications. Curr. Med. Chem. 25, 5803-5821 X. Zhang, Q. Yang, Q. Shen, J. Zheng and Z. Jia. (2018) Identification of a new nucleotide binding site by structural alignment and site directed mutagenesis. Proteins, 86, 1140-1146. P. Khanal, Z. Jia and X. Yang (2018) Cysteine residues are essential for dimerization of Hippo pathway components YAP2L and TAZ. Sci. Rep. 8:3485. M.J.Y. Lee, Y. Wang, Y. Jiang, X. Li, J. Ma, H. Tan, K. Turner-Wood, M.N. Rahman, G. Chen and Z. Jia. (2017) Function coupling mechanism of PhuS and HemO in heme degradation. Sci. Rep. 7:11273 H. Pei, S. Han, S. Yang, Z. Lei, J. Zheng and Z. Jia. (2017) Phosphorylation of bacterial L9 and its function implication in response to starvation stress. FEBS Lett. 591, 3421-3430. M.A. Currie, G. Brown, A. Wong, T. Ohira, K. Sugiyama, T. Suzuki, A.F. Yakunin and Z. Jia. (2017) Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases. RNA, 23, 346-354. Q. Shen, H. Tan, G. Xing, J. Zheng and Z. Jia. (2017) A new method to investigate the catalytic mechanism of YhdE pyrophosphatase by using a pyrophosphate fluorescence probe. Sci. Rep. 7:8169. S. Yang, Q. Shen, S. Wang, C. Song, Z. Lei, S. Han, X. Zhang, J. Zheng and Z. Jia. (2017) Characterization of C-terminal structure of MinC and its implication in evolution of bacterial cell division. Sci. Rep. 7:7627. U. Boles, C. Simpson, E.E. Gul, C. Kiss, A. Enriquez, Z. Jia, A. Baranchuk and J.S. Walia. (2017) Clinical evaluation of R860Q semi-conservative amino acid substitution in CACNA1C gene in association with long QT syndrome. Int. J. Cardiol. Heart. Vasc. 15, 21-23. R.Y. Cao, R. Eves, L. Jia, C.D. Funk, Z. Jia and A. Mak. (2017) Effects of p53-knockout in vascular smooth muscle cells on atherosclerosis in mice. PLOS ONE, 12, e0175061. D. Vukomanovic, M.N. Rahman, Z. Jia and K. Nakatsu. (2017) Drug-enhanced carbon monoxide production from heme by cytochrome P450 reductase. Med. Gas. Res. 7, 37-44. X. Zhang, Y. Jiang, Q. Mao, H. Tan, X. Li, G. Chen and Z. Jia. (2017) Distal proton shuttle mechanism of ribosome catalysed peptide bond formation - A DFT study. Molecules, 22:571. S. Yang, J. Zhu, Y. Wu, X. Wang, H. Wu, Z. Jia and J. Zheng. (2017) Purification and crystallization of MinC/FtsZc complex in Escherichia coli. Chem. Bull. 80, 89-93. Y. Jiang, X. Zhang, Q. Mao, H. Tan, X. Li, G. Chen and Z. Jia. (2017) A theoretical study on oxidative cleavage of olefins to carbonyls catalysed by Fe(III)-PyBisulidine. Dalton Trans. 46, 3825-3832. Q. Wei, S. Yang, D. Li, X. Zhang, J. Zheng and Z. Jia. (2016) A new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation. Sci. Rep. 6:28437. S. Yang, H. Pei, X. Zhang, Q. Wei, J. Zhu, J. Zheng and Z. Jia. (2016) Characterization of DicB by partially masking its potent inhibitory activity of cell division. Open Biol. 6:160082. Q. Ye, Y. Yang, L. van Staalduinen, S.W. Crawley, L. Liu, S. Brennan, G.P. C?té and Z. Jia. (2016) Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) α-kinase domain apoenzyme reveals a novel autoinhibited conformation. Sci. Rep. 6:26634. J. Qin, H. Tan, X. Li, G. Chen, J. Zheng, Y. Wang, J. Ma and Z. Jia. (2016) Theoretical studies of function switch and mechanism of AceK as a highly active ATPase. RSC Adv. 6, 68120-68127. Y. Yin, S. Li, Y. Gao, L. Tong, J. Zheng, Z. Jia, G. Jiang and Q. Wei. (2016) Loopβ3αC plays an important role in the structure and function of isocitrate dehydrogenase kinase/phosphatase (AceK). FEBS Lett. 590, 3144-3154. Y. Zhao, X. Yang, Z. Jia, R.L. Reid, P. Leclerc and F.W.K. Kan. (2016) Recombinant human oviductin regulates protein tyrosine phosphorylation and acrosome reaction. Reproduction, 152, 561-573. P.A. Meyer, S. Socias, J. Key, ........ Z. Jia, M. Crosa, P. Sliz. (2016) Data publication with the structural biology data grid supports live analysis. Nat. Commun. 7:10882. D. Li, W. Wu, H. Pei, Q. Wei, J. Zheng and Z. Jia. (2016) Expression and preliminary characterization of human MICU2. Biol. Open, 5, 962-969. D. Vukomanovic, M.N. Rahman, M.D. Maines, T.R.S. Ozolin?, W.A. Szarek, Z. Jia and K. Nakatsu. (2016) Cysteine-independent activation/inhibition of heme oxygenase-2. Med. Gas. Res. 6, 10-13. Y.H. Ouellet, C.T. Ndiaye, S.M. Gagné, A. Sébilo, M.D.L. Suits, é. Jubinville, Z. Jia, A. Ivancich and M. Couture. (2016). New insights into the heme degradation reaction by Escherichia coli O157:H7 catalyzed by ChuS. J. Inorg. Biochem. 154, 103-113. W. Wu, Q. Chen, F. Geng, L. Tong, R. Yang, J. Yang, H. Zhang, Z. Jia and Q. Wei. (2016) Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway. Immunol. Cell Biol. 94, 285-292. C. Chesterman and Z. Jia. (2016) Purification, characterization, and crystallization of membrane bound E. coli tyrosine kinase. Protein Expr. Purif. 125, 34-42. N. Wang, X. Cheng, J. Zheng, G. Chen and Z. Jia. (2016) Expression and purification of DEPTOR and its interaction with mTOR-TRD2. Chem. J. Chinese U. 5, 912-919. C. Prince and Z. Jia. (2015) An unexpected duo: Rubredoxin binds nine TPR motifs to form LapB, an essential regulator of lipopolysaccharide synthesis. Structure, 23, 1500-1506. Y. Jiang, H. Tan, J. Zheng, X. Li, G. Chen and Z. Jia. (2015) Phosphoryl transfer reaction catalyzed by membrane diacylglycerol kinase: a theoretical mechanism study. Phys. Chem. Chem. Phys. 17, 25228-25234. Y. Yang, Q. Ye, Z. Jia and G. Cote. (2015) Characterization of the catalytic and nucleotide binding properties of the alpha-kinase domain of Dictyostelium myosin-II heavy chain kinase A. J. Biol. Chem. 290, 23935-23946. W. Wu, M.N. Rahman, J. Guo, N. Roy, L. Xue, C.M. Cahill, S. Zhang and Z. Jia. (2015) Otoferlin-GAD65 coupling and its effects on GABAergic activity. J. Mol. Cell Biol. 7, 168-179. N. Wang, J. Jiang, X. Li, H. Tan, J. Zheng, G. Chen and Z. Jia. (2015) Molecular dynamics simulation studies of dTTP binding and catalysis mediated by YhdE dimerization. PLOS ONE, 10, e0134879. J. Jiang, N. Wang, Y. Jiang, H. Tan, J. Zheng and Z. Jia. (2015) Characterization of substrate binding of the WW domains in human WWP2 protein. FEBS Lett. 589, 1935-1941. B. Wheeler and Z. Jia. (2015) Preparation and characterization of human ADCK3, a putative atypical kinase. Protein Expr. Purif. 108, 13-17. J. Jin, R. Wu, J. Zhu, S. Yang, Z. Lei, N. Wang, V.K. Singh, J. Zheng and Z. Jia. (2015) Insights into the cellular function of YhdE, a nucleotide pyrophosphatase from Escherichia coli. PLOS ONE, 10, e0117823. L. M. van Staalduinen and Z. Jia. (2015) Post-translational hydroxylation by 2OG/Fe(II)-dependent oxygenases as a novel regulatory mechanism in bacteria. Front. Microbiol. 5:798. J. Jin, S. Yang, J. Zhu, J. Zheng and Z. Jia. (2015) Purification and crystallization of MinCD complex from Escherichia coli. Chem. Bull. 78, 85-88. J. Jiang, J. Zheng, Y. She and Z. Jia. (2015) Expression and purification of human WWP2 HECT domain in Escherichia coli. Protein Expr. Purif. 110, 95-101. C. Prince and Z. Jia (2014) Quantification of detergents using colorimetric methods in membrane protein crystallography. Methods Enzymol. 557, 95-116. S. Wang, Q. Shen, G. Chen, J. Zheng, H. Tan and Z. Jia. (2014) Phosphatase mechanism of bifunctional kinase/phosphatase AceK. Chem. Commun. 50, 14117-14120. Q. Wei, J. Liu, N. Wang, X. Zhang, J. Jin, I. Chin-Sang, J. Zheng and Z. Jia. (2014) Structures of an Eph receptor tyrosine kinase and its potential activation mechanism. Acta Cryst. D70, 3135-3143. L.M. van Staalduinen, F.R. McSorley, K. Schiessl, J. Séguin, P.B. Wyatt, F. Hammerschmidt, D.L. Zechel and Z. Jia. (2014) The crystal structure of PhnZ in complex with substrate reveals a new di-iron oxygenase mechanism for catabolism of organophosphonates. Proc. Natl. Acad. Sci. 111, 5171-5176. M.J.Y. Lee, F. Faucher and Z. Jia. (2014) Growth of diffraction-quality protein crystals using a harvestable microfluidic device. Cryst. Growth Des. 14, 3179-3181. M.J.Y. Lee, D. Schep, B. McLaughlin, M. Kaufmann and Z. Jia. (2014) Structural analysis and identification of PhuS as a heme-degrading enzyme from Pseudomonas aeruginosa. J. Mol. Biol. 426, 1936-1946. L.M. van Staalduinen, S.K. Novakowski and Z. Jia. (2014) Structure and functional analysis of YcfD, a novel 2-oxogluterate/ Fe2+-dependent oxygenase involved in translational regulation in E. coli. J. Mol. Biol. 426, 1896-1910. N. Wang, R. Wu, X. Cheng, J. Jin, Z. Jia and J. Zheng. (2014) New insights into mTOR structure and regulation. Chin. Sci. Bull. 59, 2927-2935. Z. Jia. (2014) Protein superglue that holds VWF together. Blood, 123, 1771-1772. J. Jin, J. Zhu, S. Yang, Z. Lei, J. Zheng and Z. Jia. (2014) Comparation studies of expression and purification of WaaP proteins from Gram-negative bacteria. Chem. Bull. 77, 1196-1201. D. Vukomanovic, M.N. Rahman, Y. Bilokin, A.G. Golub, J.F. Brien, W.A. Szarek, Z. Jia and K. Nakatsu. (2014) In vitro activation of heme oxygenase-2 by menadione and its analogs. Med. Gas Res. 4:4. J. Zheng and Z. Jia. (2013) Tiny enzyme uses context to succeed. Nature, 497, 445-446. C. Prince and Z. Jia. (2013) Detergent quantification in membrane protein samples and its application to crystallization experiments. Amino Acids, 45, 1293-1302. Q. Ye, Y. Feng, Y. Yin, F. Faucher, M.A. Currie, M.N. Rahman, J. Jin, S. Li, Q. Wei and Z. Jia. (2013) Structural basis of calcineurin activation by calmodulin. Cell Signal. 25, 2661-2667. Q. Li, J. Zheng, H. Tan, X. Li, G. Chen and Z. Jia. (2013) Unique kinase catalytic mechanism of AceK with a single magnesium ion. PLOS ONE, 8, e72048. M.A. Currie, K. Cameron, F.M.V. Dias, H.L. Spencer, E.A. Bayer, C. M.G.A. Fontes, S.P. Smith and Z. Jia. (2013) Small angle X-ray scattering analysis of Clostridium thermocellum cellulosome N-terminal complexes reveals a highly dynamic structure. J. Biol. Chem. 288, 7978-7985. B. Wahten and Z. Jia. (2013) A hierarchical order within protein structures underlies large separations between strands in β-sheets. Proteins, 81, 163-175. M.N. Rahman, D. Vukomanovic, J.Z. Vlahakis, W.A. Szarek, K. Nakatsu and Z. Jia. (2013). Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds. J. R. Soc. Interface, 10, 20120697. C. Prince and Z. Jia. (2012) Measurement of detergent concentration using 2,6-dimethylphenol in membrane-protein crystallization. Acta Cryst. D68, 1694-1696. F. Faucher and Z. Jia. (2012) High-resolution structure of AKR1a4 in apo form and its interaction with ligands. Acta Cryst. F68, 1271-1274. V.K. Singh, Kim Munro and Z. Jia. (2012) A novel calmodulin - b-PIX interaction and its implication in receptor tyrosine kinase regulation. Cell Signal. 24, 1790-1796. M.A. Currie, J.J. Adams, F. Faucher, E.A. Bayer, Z. Jia and S.P. Smith. (2012) Scaffoldin conformation and dynamics revealed by a ternary complex from the Clostridium thermocellum cellulosome. J. Biol. Chem. 287, 26953-26961. F. Faucher, S. Doublie and Z. Jia. (2012) 8-Oxoguanine DNA glycosylases: one lesion, three subfamilies. Int. J. Mol. Sci. 13, 6711-6729. V.K. Singh, M.N. Rahman, K. Munro, V.N. Uversky, S.P. Smith and Z. Jia. (2012) Free cysteine modulates the conformation of human C/EBP homologous protein. PLOS ONE, 7, e34680. J. Zheng, S. Yates and Z. Jia. (2012) Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367, 2656-2668. M.N. Rahman, J.Z. Vlahakis, D. Vukomanovic, W. Lee, W.A. Szarek, K. Nakatsu and Z. Jia. (2012) A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition. PLOS ONE, 7, e29514. B. Wathen, D.A. Pratt and Z. Jia. (2011) Hyperconjugation contributes to the bimodal distribution of glycine conformations observed in protein three-dimensional structures. ChemBioChem, 12, 1674-1677. D. Vukomanovic, B.E. McLaughlin, M.N. Rahman, W.A. Szarek, J.F. Brien, Z. Jia and K. Nakatsu. (2011) Selective activation of heme oxygenase-2 by menadione. Can. J. Physiol. Pharmacol. 89, 861-864. S. He, M. Wathier, K. Podzelinska, M. Wong, F. McSorely, A. Asfaw, B. Hove-Jensen, Z. Jia and D.L. Zechel. (2011). Structure and mechanism of PhnP, a phosphodiesterase from the carbon-phosphorus lyase pathway. Biochemistry, 50, 8603-8615. S.W. Crawley, M. Samimi, Q. Ye, Y. Yang, B. Raveh, O. Schueler-Furman, Z. Jia and G.P. Cote. (2011) Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the a-kinase domain. J. Biol. Chem. 286, 2607-2616. J.Z. Vlahakis, M.N. Rahman, G. Roman, Z. Jia, K. Nakatsu and W.A. Szarek. (2011) Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition. J. Pharmacol. Toxicol. Methods, 63, 79-88. J. Zheng and Z. Jia. (2010) Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase. Nature, 465, 961-965. B. Wathen and Z. Jia. (2010) Protein b-sheet nucleation is driven by local modular formation. J. Biol. Chem. 285, 18376-18384. J. Hong, Y. Hu, C. Li, Z. Jia, B. Xia and C. Jin. (2010) NMR characterizations of the ice binding surface of an antifreeze protein. PLOS ONE, 5, e15682. L.M. van Staalduinen, C.S. Park, S.J. Yeom, M.A. Adams-Cioaba, D.K. Oh and Z. Jia. (2010) Structure based annotation of a novel sugar isomerase from the pathogenic E. coli O157:H7. J. Mol. Biol. 401, 866-881. Y.-M. She, X. Xu, A.F. Yakunin, S. Dhe-Paganon, L.J. Donald, K.G. Standing, D. C. Lee, Z. Jia and T.D. Cyr. (2010) Mass spectrometry following mild enzymatic digestion reveals phosphorylation of recombinant proteins in Escherichia coli through mechanisms involving direct nucleotide binding. J. Proteome Res. 9, 3311-3318. K. Podzelinska, R. Latimer, A. Bhattacharya, L.C. Vining, D.L. Zechel and Z. Jia. (2010) Chloramphenicol biosynthesis: The structure of CmlS, a flavin-dependent halogenase with a covalently bound flavin. J. Mol. Biol. 397, 316-331. Q. Ye, S.W. Crawley, Y. Yang, G.P. Cote and Z. Jia. (2010) Crystal structure of the a-kinase domain of Dctyostelium myosin heavy chain kinase A. Sci. Signal. 3, ra17. J.J. Adams, M.A. Currie, E.A. Bayer, Z. Jia and S.P. Smith. (2010) Insights into higher order organization of the cellulosome revealed by a dissect-and-build approach: Crystal structure of interacting Clostridium thermocellum multimodular components. J. Mol. Biol. 396, 833-839. M.A Currie, J.J Adams, S. Ali, S.P Smith and Z. Jia. (2010) Purification and crystallization of a multimodular heterotrimeric complex containing both type-I and type-II cohesin-dockerin interactions from the cellulosome of Clostridium thermocellum. Acta Cryst. F66, 327-329. R. Gordienko, H. Ohno, V.K. Singh, Z. Jia, J.A. Ripmeester and V.K. Walker. (2010) Towards a green hydrate inhibitor: Imaging antifreeze proteins on clathrates. PLOS ONE 5:e8953. M.N. Rahman, J.Z. Vlahakis, G. Roman, D. Vukomanovic, W.A. Szarek, K. Nakatsu and Z. Jia. (2010) Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors. J. Inorg. Biochem. 104, 324-330. Y. Zhang, H. Tan, G. Chen and Z. Jia. (2010) Investigating the disorder-order transition of calmodulin binding domain upon binding calmodulin using molecular dynamics simulation. J. Mol. Recognit. 23, 360-368. B. Wathen and Z. Jia. (2010) Residue patterning in helix interiors. Biochem. Cell Biol. 88, 325-327. B. Wathen, Z. Jia and V.K. Walker. (2010) Modeling the interactions between poly(N-vinylpyrrolidone) and gas hydrates: Factors involved in suppressing and accelerating hydrate growth. Lect. Notes Comput. Sci. 5976, 117-133. D. Vukomanovic, B. McLaughlin, M.N. Rahman, J.Z. Vlahakis, G. Roman, R.A. Dercho, R.T. Kinobe, J.F. Brien, Z. Jia, W.A. Szarek and K. Nakatsu. (2010) Recombinant truncated and microsomal heme oxygenase-1 and -2: Differential sensitivity to inhibitors. Can. J. Physiol. Pharmacol. 88, 480-486. G. Roman, M.N. Rahman, D. Vukomanovic, Z. Jia, K. Nakatsu and W.A. Szarek. (2010) Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: Effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chem. Biol. Drug Des. 75, 68-90. D. Lee and Z. Jia. (2009) Emerging structural insights into bacterial tyrosine kinases. Trends Biochem. Sci. 34, 351-357. M.A. Currie, F. Merino, T. Skarina, A.H.Y. Wong, A. Singer, G. Brown, A. Savchenko, A. Caniuguir, V. Guixe, A.F. Yakunin and Z. Jia. (2009) ADP-dependent 6-phosphofructokinase from Pyrococcus horikoshii OT3: Structure determination and biochemical characterization of Ph1645. J. Biol. Chem. 284, 22664-22671. J. Zheng, A.X. Ji and Z. Jia. (2009) Purification, crystallization and preliminary X-ray analysis of bifunctional isocitrate dehydrogenase kinase/phosphatase in complex with its substrate isocitrate dehydrogenase in Escherichia coli. Acta Cryst. F65, 1153-1156. A. Matte, G. Kozlov, J.-F. Trempe, M.A. Currie, D. Burk, Z. Jia, K. Gehring, I. Ekiel, A.M. Berghuis and M. Cygler. (2009) Preparation and characterization of bacterial protein complexes for structural analysis. In Advances in Protein Chemistry and Structural Biology (Elsevier), 76, 1-42. T. Lu, H. Tan, D. Lee, G. Chen and Z. Jia. (2009) New insights into the activation of Escherichia coli tyrosine kinase revealed by molecular dynamics simulation and biochemical analysis. Biochemistry, 48, 7986-7995. M.N. Rahman, J.Z. Vlahakis, D. Vukomanovic, W.A. Szarek, K. Nakatsu and Z. Jia. (2009) X-ray crystal structure of human heme oxygenase-1 with (2R, 4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[{(5-trifluoromethyl-pyridin-2-yl)thio}methyl]-1,3-dioxolane: A novel, inducible binding mode. J. Med. Chem. 52, 4949-4950. J. Guo, H. Massaeli, J. Xu, Z. Jia, J.T. Wigle, N. Mesaeli and S. Zhang. (2009) Extracellular potassium concentration controls cell surface hERG channel density. J. Clin. Invest. 119, 2745-2757. B. Wathen and Z. Jia. (2009) Folding by numbers: The statistics of primary sequences and their use in studying protein folding. Int. J. Mol. Sci. 10, 1567-1589. K. Podzelinska, S.-M. He, M. Wathier, A. Yakunin, M. Proudfoot, B. Hove-Jensen, D.L. Zechel and Z. Jia. (2009) Structure of PhnP: A phosphodiesterase of the carbon-phosphorous lyase pathway for phosphonate degradation. J. Biol. Chem. 284, 17216-17226. J. Zheng, D. Lee and Z. Jia. (2009) Purification, crystallization and preliminary X-ray analysis of isocitrate dehydrogenase kinase/phosphatase in Escherichia coli. Acta Cryst. F65, 536-539. M.D.L. Suits, J. Lang, G.P. Pal, M. Couture and Z. Jia. (2009) Structure and heme binding properties of Escherichia coli O157:H7 ChuX. Protein Sci.18, 825-838. J.Z. Vlahakis, M. Hum, M.N. Rahman, Z. Jia, K. Nakatsu and W.A. Szarek. (2009) Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: Effect of substituents at the 4-position of the dioxolane ring. Bioorg. Med. Chem. 17, 2461-2475. T.G Wright, V. Singh, J.J. Li, J. Foley, F.R. Miller, Z. Jia and B.E. Elliott. (2009) Increased production and secretion of HGF alpha-chain and an antagonistic HGF fragment in a human breast cancer progression model. Int. J. Cancer, 125, 1004-1015. R. Latimer, K.PodzelinskaA. Soares, A. Bhattacharya, L.C. Vining, Z.Jia and D. Zechel. (2009) Expression, purification and preliminary diffraction studies of CmlS. Acta Cryst. F65, 260-263 A. Matte, I. Ekiel, Z. Jia, K. Gehring and M. Cygler. (2009) A medium-throughput structural proteomics approach applied to the genome of E. coli. In Sytstems Biology and Biotechnology of Escherichia coli (Ed. S. Y. Lee). Springer 59-79. V.A. McPherson, S. Everingham, R. Karisch, J.A. Smith, C.M. Udell, J. Zheng, Z. Jia and A.W.B. Craig. (2009) Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcεRI pathway in mast cells. Mol. Cell. Biol. 29, 389-401.

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